Neurology
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Cumulative Estrogen Exposure Linked to Lower Stroke Risk
These findings could help clinicians sustain their postmenopausal patients’ neurological health.
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Lecanemab-irmb Injection (Leqembi)
Lecanemab can be prescribed to treat Alzheimer's disease. Initiate this treatment in patients with mild cognitive impairment or mild dementia stage of disease, with confirmation of amyloid beta pathology.
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In Med/Mal Cases for Missed Central Nervous Pathology, Dizziness Is Factor
After reviewing dozens of malpractice claims, researchers learned patients who reported dizziness often were discharged home or admitted without anyone diagnosing central nervous system pathology. Patients presented to an ED and were diagnosed with migraine or other conditions. The correct diagnoses only became clear later. The subsequent lawsuits revolved around the first emergency physician missing the diagnosis at the initial visit.
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Poor Cardiovascular Health a Predictor for Premature Brain Aging
Worse cardiovascular health at age 36 years can predict worse brain aging and associated cognitive problems later in life.
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Efficacy and Safety of Leriglitazone in Patients with Friedreich Ataxia
Friedreich ataxia (FRDA) is an autosomal, recessive, multisystemic disease characterized by progressive weakness, ataxia, and dysarthria starting in childhood and resulting in severe morbidity and premature death. There are no approved treatments for FRDA. With recent preclinical studies suggesting potential benefit of PPARPγ agonists in motor function and reduced radiographic disease activity, the current study explores the effect of leriglitazone, a PPARPγ agonist, in patients with moderate to severe FRDA.
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Late-Onset Pompe Disease: A Review of Clinical Features
In this systematic literature review of studies that evaluate motor and locomotion function in patients with adult, late-onset Pompe disease, the clinical spectrum reveals weakness of respiratory, axial, and proximal limb muscles.
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Can a Blood-Based Test Serve as a Biomarker for Parkinson’s Disease?
This proof-of-concept study proposes that a noninvasive assay detecting pathology-associated α-synuclein extracted from blood may reveal a reliable biomarker for Parkinson’s disease.
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Do Spinal Cord Stimulators Really Help for Chronic Pain?
A comprehensive analysis of a large clinical database regarding treatment of patients with chronic low back pain did not support the benefit of spinal cord stimulators compared to conventional medical management for chronic pain.
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Magnetic Brain Stimulation for Alzheimer’s Disease
Transcranial magnetic stimulation, targeted at the precuneus in an effort to maintain a normal default mode network, shows some promise in slowing cognitive decline and maintaining normal electrophysiology in patients with mild to moderate Alzheimer’s disease.
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Body Weight Decline in Cognitively Intact Older Adults May Predict Future Cognitive Impairment
Among cognitively intact individuals, those who developed mild cognitive impairment (MCI) recorded faster body mass index (BMI) decline and significantly lower BMI seven years before MCI diagnosis.