Neurology
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Lower Risk of Parkinson’s Disease After Vagotomy: Implications for Spread of Pathology
Truncal vagotomy was associated with a reduced risk for Parkinson’s disease with a hazard ratio of 0.58 for those with more than 20 years’ follow-up. This suggests the vagus nerve as a possible route of entry into the central nervous system for this neurodegenerative process.
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Potential Imaging Biomarkers of SUDEP: Can We Predict Sudden Death in Epilepsy?
The authors retrospectively conducted a voxel-based analysis of T1 MRI scans to compare gray matter volumes in 12 cases of sudden unexpected death in epilepsy (SUDEP) acquired at a median of 2 years before death with patients at high or low risk for SUDEP and with healthy controls, and demonstrated significant anatomical differences between the groups.
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Autoimmune Cerebellar Ataxia — Responses to Treatment
This study analyzed patients diagnosed with antibody-mediated paraneoplastic and non-paraneoplastic cerebellar ataxia, and treatment benefit was seen predominantly in the non-paraneoplastic group.
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Clinical Briefs
In this section: improving cardiovascular outcomes through early treatment of diabetes; re-thinking PTSD treatment in veterans; and a link between rosacea and cardiovascular disease.
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Flibanserin Tablets (Addyi)
The FDA has approved the first drug for the treatment of hypoactive sexual desire disorder in women.
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The Impact of Hypoglycemia on Renal Impairment
A retrospective cohort study evaluated renal function data of 101 patients with type 2 diabetes and a history of severe hypoglycemia compared with a matched group of individuals with type 2 diabetes with no history of hypoglycemia.
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Efficacy and Safety of Very Early Mobilization After Onset of Acute Stroke
The higher dose, very early (within 24 hours) mobilization protocol was associated with a reduction in the odds of a favorable outcome at 3 months after stroke occurrence.
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SPRINT: The Systolic Blood Pressure Trial or ‘How Low Do You Go?’
Designed to see if lower blood pressures reduced the risk of blood pressure-related health outcomes, the NIH ended the SPRINT trial early and issued a news release that a lower blood pressure target significantly reduces cardiovascular complications in adults age 50 and older with high blood pressure.
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Valve Disease and Thromboembolic Risk
The CHA2DS2-VASc score for the prediction of stroke and other thromboembolism risk in patients with atrial fibrillation has been validated in patients with non-valvular atrial fibrillation.
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Using Procalcitonin to Differentiate Bacterial from Viral Meningitis
SYNOPSIS: A meta-analysis based on nine studies found an elevated serum procalcitonin to be an accurate test for differentiating bacterial from viral meningitis in adults.