Neurology
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A Rivaroxaban/Daily Low-dose Aspirin Combination and Cardiovascular Events
The addition of rivaroxaban to daily low-dose aspirin resulted in fewer cardiovascular outcomes and increased major bleeding compared to aspirin alone in patients with stable cardiovascular disease.
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A Cup of Coffee May Help Patients Live Longer
In a prospective cohort of patients coinfected with HIV and hepatitis C virus, drinking three or more cups of coffee per day halved the all-cause mortality risk.
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Migraine With Aura, Stroke Risk, and Biomarkers
A longitudinal cohort study of twins found no increased stroke risk related to migraine overall, but there was a modestly increased risk for stroke related to migraine with aura. Familial factors and vascular biomarkers associated with migraine with aura may explain its correlation with vascular disease.
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Diabetes, HbA1c, and Neuropathy
The hallmark of neuropathy associated with type 2 diabetes is reduction of sensory nerve action potential amplitude and not a reduction in conduction velocity, supporting the hypothesis that hyperglycemia causes axonal dysfunction and injury.
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Noninvasive Vagus Nerve Stimulation for Indomethacin-Sensitive Headaches
Trigeminal autonomic cephalgias are notoriously difficult to treat and may be responsive to noninvasive vagus nerve stimulation.
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Childhood Head Trauma and Risk of Subsequent Diagnosis of Multiple Sclerosis
A large study that reviewed longitudinally collected data from the national Swedish Patient Register found that head trauma in adolescents was associated with an increased risk of subsequent diagnosis of multiple sclerosis.
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Exploring Cortical Pathology in Multiple Sclerosis With Routine MRI
In this MRI and histopathological study, the investigators showed that cortical T1w/T2w ratio was unrelated to myelin density, but had a strong correlation with dendritic density. Furthermore, abnormal values within the posterior cingulate cortex correlated with impairment in cognitive domains.
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Pitfalls in the Treatment of Seizures Associated With Brain Tumors
In this multicenter, observational study, the authors assessed the prevalence of neuropsychiatric side effects from medications in subjects with tumor-related epilepsy. Levetiracetam was found to have the highest prevalence of such side effects.
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Caring for Providers: Mindfulness for Healthcare Practitioners
Preliminary studies show some promise for use of mindfulness interventions in healthcare practitioners, but the time required for training medical providers in these techniques is identified as a limitation to implementation.
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Angiotensin II Raises Blood Pressure in Patients with Vasodilatory Shock
The ATHOS-3 trial represents an important proof of concept trial regarding angiotensin II as a new vasopressor in the armamentarium to treat vasodilatory shock.