Neurology
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Salivary microRNA as Biomarker to Predict Prolonged Concussion Symptoms
In a prospective cohort study of pediatric patients, aged 7 to 21 years, diagnosed with concussion, salivary microRNAs were found to be a potential biomarker for predicting prolonged concussion symptoms.
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Treatment for Autoimmune Small-fiber Neuropathy
The cause of most cases of small-fiber neuropathy is uncertain, but many patients have accompanying autoimmune biomarkers. In a carefully selected group of such patients, intravenous immunoglobulin treatment appears to provide benefit.
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Proceedings From the International Stroke Conference, Los Angeles, February 2018
Message from the editor: The following reviews of studies presented at the 2018 International Stroke Conference were written after my personal attendance at the presentations, followed by review of the simultaneous publications in the journals Stroke, The New England Journal of Medicine, JAMA Neurology, and the Journal of the American Medical Association.
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Clinical Briefs
In this section: tackling insomnia with cognitive behavioral therapy; navigating the spurious claims of internet-advertised products; and updated guidelines regarding hypertension treatment.
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Ozenoxacin Cream 1% (Xepi)
Ozenoxacin is indicated for the topical treatment of impetigo due to S. aureus and S. pyogenes in adult patients and pediatric patients ≥ 2 months of age.
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Updated Recommendations for Prevention of Hepatitis B Virus Infection
Fresh recommendations for prevention of hepatitis B virus infection focus on testing and management of newborns.
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Functional Imaging Studies in Parkinson’s Disease
A meta-analysis of 142 studies demonstrated that functional imaging studies in Parkinson’s disease using tracers for aromatic acid decarboxylase showed smaller defects compared to those using tracers targeting dopamine transport and VMAT2. Symptom severity correlated linearly with dopamine neuron loss as determined by these imaging studies.
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A Closer Look at the Effects of NSAIDs on Blood Pressure
An ambulatory blood pressure monitoring substudy of the PRECISION trial showed that ibuprofen use significantly increased mean 24-hour systolic blood pressure compared to celecoxib. Further, naproxen produced intermediate results despite equivalent pain relief in patients with arthritis.
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Kratom Alert: FDA Concerns
Kratom, a plant that is banned in some countries, is available in the United States and has some safety concerns, mostly related to its opioid-like effects.
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Anything Other Than RBBB?
The ECG in the figure was obtained from a 60-year-old woman who presented to the ED with new-onset chest pain. The initial emergency care provider interpreted this tracing as showing complete right bundle branch block. Do you agree?