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Occipital Nerve Stimulation in Medically Intractable Chronic Cluster Headache

Occipital nerve stimulation is an effective and safe treatment that can help reduce attack frequency and intensity in patients with medically intractable chronic cluster headache.

Dietary Modifications with Linoleic Acid Can Have an Effect on Gut and Brain Inflammation

This study evaluated the use of dietary conjugated linoleic acid (CLA) supplementation to modulate the disease outcome in a spontaneous mouse model of central nervous system autoimmunity and also studied patients with relapsing-remitting multiple sclerosis receiving CLA supplementation. CLA may act as a modulator of the gut-brain axis by targeting immune cells in the gut, with a subsequent effect in the brain.

Neuromuscular Complications of Graft-Versus-Host Disease

Graft-versus-host disease is common in allogeneic bone marrow recipients, but neuromuscular complications are unusual (8%). The most common neuromuscular complication is an immune-mediated myositis that responds to treatment with immunosuppressive therapies.

CSF Biomarkers May Distinguish MSA from Lewy-Body Alpha-Synucleinopathies Before the Onset of Debilitating Symptoms

In patients with autonomic failure, the combination of elevated neurofilament light and alpha-synuclein oligomers in the cerebrospinal fluid can distinguish between multiple system atrophy and Parkinson’s disease/dementia with Lewy bodies. Early diagnosis is critical for the development of treatment trials.

Recovery of Consciousness After TBI: Who Recovers and When?

The majority of patients with moderate to severe traumatic brain injury who survive and are treated in acute rehabilitation centers will recover consciousness.

Back Pain-Related Disability and Lumbar Spine Imaging Changes

A population-based, prospective cohort study of women in the United Kingdom found no association between the number of lumbar segments with radiographic pathology and severity of back pain-related disability.

Prophylaxis for Tuberculosis in Patients with Myasthenia Gravis

In this observational study from an area with a high rate of endemic tuberculosis (TB), prophylactic treatment of TB was appropriate in those treated with high doses of prednisone and evidence of prior TB infection.

Long-Term Effects of Cholinesterase Inhibitors on Cognitive Decline and Mortality

Cholinesterase inhibitors are one of the few drug classes approved by the Food and Drug Administration for the treatment of patients with Alzheimer’s disease. This study shows a long-term benefit in slowing the decline of cognition, as measured by the Mini-Mental State Exam, but it is unclear if there is any benefit in quality of life.

Genetic Biomarkers of Immunoglobulin Response in Patients with CIDP

Nearly 25% of patients with chronic inflammatory demyelinating polyneuropathy (CIDP) have a poor response to intravenous immunoglobulin treatment. Variations in the PRF1 and FCGR2B genes in CIDP patients offer insights into the heterogenous treatment response.

Association of Sleepwalking and REM Sleep Behavior Disorder in Men with Parkinson’s

In this retrospective, cross-sectional study of men, both sleepwalking and rapid eye movement sleep behavior disorder were associated with the development of Parkinson’s disease.