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Treatment of Seizures After Spontaneous Intracerebral Hemorrhage

The reported incidence of post-stroke seizures varies and appears to have a higher incidence following hemorrhagic stroke. Post-stroke seizures have been associated with a greater length of hospitalization, increased mortality, and complications. This study compared four seizure prophylaxis strategies to determine the greatest net benefit for patients with spontaneous intracerebral hemorrhage. There was a better outcome with short-term antiepileptic medication use compared to long-term use.

Cortical Lesions Correlate with Disability in Patients with Multiple Sclerosis

In a long-term, 30-year follow-up study of a cohort of patients with multiple sclerosis who presented with clinically isolated syndrome, the investigators found that, among the variables assessed, the presence of cortical lesions had the highest association with long-term physical and cognitive disability.

Proteomics: A New Method to Understand the Influence of Genetic Variation on Disease Pathogenesis

The combination of genome-wide association studies with the analysis of messenger ribonucleic acid and unique proteins in the brain, cerebrospinal fluid, and plasma can shed new light on our understanding of the genetic risks for the development of various neurological diseases.

What Is Focal CIDP?

Chronic inflammatory demyelinating polyneuropathy (CIDP) usually is diagnosed in patients who have a generalized disorder. However, there are focal syndromes that have been observed and diagnosed under different names that meet many of the clinical and electrodiagnostic criteria of CIDP and may be referred to as “focal” CIDP.

MRI Changes and Functional Outcomes Among Adults with Severe HSV Encephalitis

Herpes simplex virus is a common cause of encephalitis worldwide. When treated promptly, the mortality rate decreases from 70% to 15%, but many patients remain disabled. This multicenter cohort study analyzed magnetic resonance imaging in patients diagnosed with herpes simplex encephalitis admitted to the intensive care unit to identify factors associated with poor outcome at 90 days.

The Passing of M. Flint Beal, MD

A tribute to the late M. Flint Beal, MD.

Localized Slow Wave Sleep in the Awake but Inattentive Brain

Electroencephalogram studies of humans during periods of “mind wandering” and “mind blanking” have shown regional changes that suggest parts of the brain may be asleep while other areas are activated.

Is it Chronic Inflammatory Demyelinating Polyneuropathy or Charcot-Marie-Tooth Disease?

Charcot-Marie-Tooth disease may be confused with chronic inflammatory demyelinating polyneuropathy, resulting in inappropriate and hazardous treatments. Age at onset < 40 years, a family history of neuropathy, absence of nerve hypertrophy on magnetic resonance imaging, and poor response to intravenous immune globulin treatment should prompt a genetic evaluation.

Functional Cognitive Disorder: An Important Condition for Neurologists to Recognize

Functional cognitive disorder (FCD) is a term that can be used to describe cognitive difficulties that are present where there is no biologic cause, but a lack of consensus in diagnostic criteria limits its use in clinical practice and research. Ball and colleagues proposed an operational definition for FCD as the cognitive phenotype of functional neurological disorder.

Mortality and Costs of Status Epilepticus

In an analysis of a large group of patients hospitalized with status epilepticus, based on an administrative database, patients who required a third line of intravenous anesthetic agents had the highest mortality and highest hospital costs.