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Intravenous immunoglobulin treatment for the first year from onset of the first neurological event suggestive of demyelinative disease significantly lowers the incidence of a second attack and reduces disease activity as measured by brain magnetic resonance imaging.
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The observed increase in risk of stroke among individuals homozygous for the MTHFR T allele is close to that predicted from the differences in homocysteine concentration conferred by this variant.
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IgG from all narcolepsy patients significantly enhanced bladder contractile responses to the muscarinic agonist carbachol and neuronally released acetylcholine, as compared to the control IgG.
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Extraocular muscles have fundamentally distinct structural, functional, biochemical and immunological properties compared to other skeletal muscles. While these properties enable high fatigue resistance and the rapid and precise control of extraocular motility, they might also explain why extraocular muscles are selectively involved in certain disorders, such as chronic progressive external ophthalmoplegia, myasthenia gravis, and Graves ophthalmopathy.
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Pure sensory clinical phenotype, low median and ulnar terminal latency index, and absence of M responses in the lower limbs were significantly associated with the diagnosis of MAG-PN, and indicate a moderate to large increase in probability of this diagnosis in patients with chronic dysimmune demyelinating polyneuropathies.
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The findings support the efficacy and safety of the use of bilateral stimulation of the internal globus pallidus in selected patients with primary generalized dystonia.
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Epilepsy duration is the most important predictor for long-term surgical outcome.
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The most commonly prescribed statins have a low incidence of rhabdomyolysis, according to the results a new study of more than 250,000 patients.
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Vitamin E had no significant effects in slowing disease progression, and no significant side effects in the patient population were encountered. Patients who regularly take vitamin E have a 60% reduced risk of getting ALS.
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These data prove the high diagnostic value of our objective EEG criteria in CJD.
