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Lecanemab-irmb Injection (Leqembi)

Lecanemab can be prescribed to treat Alzheimer's disease. Initiate this treatment in patients with mild cognitive impairment or mild dementia stage of disease, with confirmation of amyloid beta pathology.

Vaccination Against Mpox: Does It Work? Is It Safe?

Vaccination, either subcutaneously or intradermally, with the non-replicating Jynneos monkeypox vaccine is safe and effective.

Resistance of SARS-CoV-2 Variants to Monoclonal Antibodies

Prevalent SARS-CoV-2 variants are persistently resistant to therapeutic and prophylactic monoclonal antibodies but remain susceptible to nirmatrelvir/ritonavir, remdesivir, and molnupiravir.

Chlorthalidone vs. Hydrochlorothiazide: Which Is Superior for Treating Hypertension?

Randomly switching half of patients with hypertension on hydrochlorothiazide to chlorthalidone did not produce any difference in major cardiovascular outcomes.

For Older Americans, More Steps Lead to Better Cardiovascular Health

In a meta-analysis, researchers found walking 6,000 to 9,000 steps daily lowered the risk of cardiovascular disease by 40% to 50% vs. walking 2,000 steps daily.

Tocilizumab Injection (Actemra)

The FDA has approved tocilizumab injection to treat COVID-19 among hospitalized adult patients who are receiving systemic corticosteroids and require supplemental oxygen.

Current and Future Options for Male Contraception

The following is a summary of the existing male contraceptive options and an overview of future ones.

New Therapy for Resistant Hypertension

Aprocitentan demonstrated efficacy for additional therapy beyond standard multidrug treatment in resistant hypertension.

Is It Better to Up-Titrate Medications Faster in Acute Heart Failure Patients?

Early intensive up-titration of guideline-recommended therapy in patients admitted for heart failure reduced 180-day readmission and all-cause mortality rates at the cost of more adverse events (but not serious or fatal ones).

Low-Fat vs. Mediterranean Diet for Secondary Prevention

A study of stable coronary heart disease patients comparing the Mediterranean diet to a low-fat diet over a seven-year follow-up showed the Mediterranean diet was superior at preventing major cardiovascular events.