Internal Medicine Alert
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Antibiotics and Adverse Events: Doctors, Do No Harm
A retrospective study found that among 1,488 hospitalized patients who received an antibiotic, 298 experienced at least one antibiotic-associated adverse drug event. Furthermore, 287 of the antibiotic regimens were not clinically indicated, and 56 of these were associated with an adverse drug event.
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Are Right-sided Leads Needed?
The ECG in the figure was obtained from a man in his 50s who presented with new severe chest pain. How would you interpret this tracing? What area(s) of the heart are involved? What is the likely culprit artery?
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Clinical Briefs
In this section: opioid-induced nausea; considering the safety of proton pump inhibitors; and life after bariatric surgery.
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Secnidazole Oral Granules (Solosec)
Secnidazole is indicated for the treatment of bacterial vaginosis in adult women.
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Oily Fish Is Associated With Better Sleep
A study in Ecuador showed a strong positive correlation between dietary oily fish intake and sleep quality.
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A Rivaroxaban/Daily Low-dose Aspirin Combination and Cardiovascular Events
The addition of rivaroxaban to daily low-dose aspirin resulted in fewer cardiovascular outcomes and increased major bleeding compared to aspirin alone in patients with stable cardiovascular disease.
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A Cup of Coffee May Help Patients Live Longer
In a prospective cohort of patients coinfected with HIV and hepatitis C virus, drinking three or more cups of coffee per day halved the all-cause mortality risk.
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Clinical Briefs
In this section: A better definition for celiac disease; shedding light on a vaccine; and treating asthma.
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Meropenem and Vaborbactam Injection (Vabomere)
The FDA has approved a new combination antibacterial for the treatment of complicated urinary tract infections.
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Is a Dabigatran Reversal Agent Effective?
A pragmatic clinical study of idarucizumab for counteracting the effects of the oral anticoagulant dabigatran showed rapid and complete reversal of its effects in patients with major bleeding or urgent surgery, without any adverse safety concerns.