Internal Medicine Alert
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Tucatinib Tablets (Tukysa)
Tucatinib should be prescribed in combination with trastuzumab and capecitabine to treat adults with advanced unresectable or metastatic HER2-positive breast cancer.
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For Knee Arthritis: Physical Therapy or the Needle?
In a small, randomized, controlled trial of patients with knee osteoarthritis, those who received physical therapy reported less pain and functional disability at one year than those who received one or more glucocorticoid intra-articular injections. -
Empiric Anti-MRSA Therapy in Pneumonia May Not Always Be a Good Idea
In a retrospective cohort study, empiric anti-methicillin-resistant Staphylococcus aureus treatment was not associated with a reduction in mortality in any subgroup of patients studied and appeared to cause harm in many.
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Acute Myocardial Infarction, or Acute Pericarditis?
The lack of significant Q waves, lack of any reciprocal ST depression, and the prominent J-point notching in the figure all suggest this may not be an acute infarction.
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Ozanimod Capsules (Zeposia)
Ozanimod should be prescribed to treat relapsing multiple sclerosis, including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.
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Cannabis for Mental Health Disorders: Follow the Evidence
In a review of 83 eligible studies, researchers found little evidence to support the efficacy of cannabinoids to treat depressive disorders, anxiety disorders, or several other mental health disorders.
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The Cascade Effect: Calcium Channel Blockers and High Blood Pressure
Many older adults who are prescribed calcium channel blockers subsequently receive a loop diuretic. Awareness of this common cascade may reduce unnecessary prescribing and potential harm.
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More Mediterranean Diet Benefits: Diverse Microbiomes, Better Health Among Seniors
A randomized, multicenter study showed that eating a Mediterranean diet for one year improved the diversity of the gut microbiome in older subjects and was associated with reduced frailty and better health.
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Osilodrostat Tablets (Isturisa)
Osilodrostat should be prescribed to adult patients with Cushing's disease for whom pituitary surgery is not an option or has not been curative.
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Cannabis in the Treatment of Headache and Migraine
The authors of this observational study found nearly a 50% reduction in self-reported headache and migraine severity following use of inhaled medicinal cannabis.