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By Malcolm Robinson, MD, FACP, FACG
Emeritus Clinical Professor of Medicine, University of Oklahoma College of Medicine, Oklahoma City, OK
Disclosure; Dr. Robinson serves as a consultant for TAP, Pfizer, Janssen, Eisai, J&J-Merck, and Procter & Gamble, is on the speakers bureau of Janssen, Eli Lilly, Solvay, TAP, and Aventis, and does research for Forest Labs, Wyeth-Ayerst, AstraZeneca,and Centocor.
Synopsis: Rifaximin, a newly released nonabsorbed antibiotic, appears to safely and effectively prevent the onset and substantial morbidity of travelers diarrhea.
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By William T. Elliott, MD, FACP, and James Chan, PharmD, PhD
Dr. Elliott is Chair, Formulary Committee, Northern California Kaiser Permanente; Asst. Clinical Professor of Medicine, University of California, San Francisco; Dr. Chan is Pharmacy Quality and Outcomes Manager, Kaiser Permanente, Oakland, CA
Drs. Chan and Elliott report no financial relationships to this field of study.
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Staphylococcal Toxins in Patients with Psoriasis, Atopic Dermatitis, Erythroderma, and in Healthy Control Subjects; Insulin Resistance and Risk of Congestive Heart Failure; Ciprofloxacin Interacts with Thyroid Replacement Therapy
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Premature Ischemia
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Beta-Blockers May Be Useful for Noncardiac Surgery; Promising New Weight Loss Drug?; Treating Shift-Work Disorder; Another Flu Vaccine Shortage?; FDA Actions
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Symptoms of lower extremity venous disease are directly related to the degrees of visible and functional disease, but may occur even in legs that appear normal.
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Two recent studies shed further light on the short-term use of parathyroid hormone (PTH) to enhance the treatment of osteoporosis. PTH is approved for use up to 2 years in patients with moderate-to-severe osteoporosis. The anabolic bone formation induced by PTH is largely lost after stopping therapy, but is well maintained by continued therapy with a biphosphonate. PTH may be given continuously or cyclically to enhance bone formation.
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Women with polycystic ovaries demonstrate a definite rate of worsening glucose tolerance and conversion to type 2 diabetes mellitus.
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The FDA has approved tigecycline, the first of a new class of antimicrobial agents. The drug is a novel parenteral antibiotic that is chemically similar to minocycline. It is active against a wide variety of bacteria that cause complicated intra-abdominal and complicated skin and skin structure infections including methicillin-resistant Staphylococcus aureus (MRSA). Tigecycline is marketed by Wyeth as Tygacil.
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