Internal Medicine Alert
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Hypoglycemia Increases Cardiovascular Risk in Patients With Type 1 and Type 2 Diabetes
This is a retrospective analysis of data from the UK Clinical Practice Research Datalink which includes 265,868 insulin-treated patients age > 30 years diagnosed with diabetes between 2001 and 2007. 3260 were diagnosed with T1DM and 10,422 had T2DM. During a median follow-up of 5 years for type 1 diabetes patients and 4.8 years for those with type 2 diabetes, hypoglycemia was experienced by 573 (18%) and 1463 (14%) of patients, respectively. Compared with patients who did not experience hypoglycemia, the hazard ratio (HR) for CV events among T1DM patients who experienced hypoglycemia was 1.51 (not significant) and 1.61 for those with and without a history of CVD. For T2DM patients, the respective HRs were 1.60 and 1.49. The median time interval between the first hypoglycemia event and the first CV event was 1.5 years for all diabetes patients. Thus, hypoglycemia increases the risk of both CV and all-cause mortality in patients with diabetes.
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Influenza, 2014-2015 — Something Old, Something New, and a Mismatch
By early January, influenza activity had reached epidemic proportions in large parts of the United States, despite prior vaccination.
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Pharmacology Watch
Tiotropium for uncontrolled asthma, sibutramine pulled from market, incidence and mortality data from WHI, FDA Actions -
Psoriasis: A Risk Factor for MI?
Psoriasis sufferers may face an increased risk of having a heart attack, a new study suggests. The risk appears to be most pronounced among younger patients with more severe forms of the disease. -
Meal Size More Important Than Calorie Content
Both overweight and normal-weight persons underestimated calorie content of large meals but not smaller meals. Since overweight persons ate larger size meals, they consumed more unnecessary calories. -
Deep Dive: How Nose Picking Affects Nasal Carriage of Staph
Overcoming the habit of nose picking may aid S. aureus decolonization strategies. -
Importance of HDL Cholesterol in ACS
Regardless of baseline low-density lipoprotein cholesterol levels and statin therapy, additional strategies to increase HDL cholesterol should be evaluated in patients with acute coronary syndrome. -
Traveler's Diarrhea and Irritable Bowel Syndrome
The symptoms of irritable bowel syndrome may occur after gastrointestinal infection in some individuals. -
Clinical Briefs By Louis Kuritzky, MD
After prostatectomy, many men lose erectile function. It has been recently noted that penile stimulation that actively produces cavernosal dilation may reduce the likelihood of loss of function. -
Sitagliptin Phosphate Tablets (Januvia™)
The FDA has approved the first of a new class of drugs for the treatment of type 2 diabetes. Sitagliptin is a dipeptidyl peptidase-IV (DPP-4) inhibitor.