Internal Medicine Alert
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Clinical Briefs
In this section: Are annual physicals worth it?; breakfast might be the most important meal of the day; and evaluating the total knee replacement. -
Insulin Degludec Injection (Tresiba)
Insulin degludec provides an alternative to insulin glargine and insulin detemir as long-acting human insulin analogs.
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Beta-blocker Dose More Important Than Heart Rate in Systolic Heart Failure
In chronic heart failure with reduced ejection fraction, titrating beta-blocker doses may confer a greater benefit than reducing heart rate.
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Using Procalcitonin to Differentiate Bacterial from Viral Meningitis
A meta-analysis based on nine studies found an elevated serum procalcitonin to be an accurate test for differentiating bacterial from viral meningitis in adults.
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Risk of New Onset Diabetes When Blood Pressure Becomes Elevated Over the Usual Measurement
An increase of 20 mmHg in systolic blood pressure was associated with a 58% higher risk of new-onset diabetes mellitus, whereas an increase of 10 mmHg in diastolic blood pressure was associated with a 52% higher risk of developing new-onset diabetes mellitus.
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Clinical Briefs
In this section: managing osteoporosis, comparing treatments for hypertension, and uric acid as a predictor of hypertension.
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Idarucizumab Injection (Praxbind)
Idarucizumab effectively reverses the anticoagulant effect of dabigatran and has minimal side effects.
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Treatment for Ulnar Neuropathy at the Elbow
In a randomized treatment trial of steroid injection into the cubital tunnel for ulnar neuropathy, there was no difference in outcome compared to placebo.
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Eat Breakfast, Fix Insulin Resistance in Patients with Type 2 Diabetes
Breakfast consumption could be a successful strategy for reducing postprandial hyperglycemia in patients with type 2 diabetes.
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Eat Right, Preserve Your Memory, and Stay Happy
Greater intake of unhealthy food and lower intake of nutrient-dense food is associated with a smaller hippocampus over 4 years in adults 60-64 years of age.