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COVID-19 Vaccination: The Heart of the Matter

The occurrence of myocarditis after receipt of COVID-19 vaccines is most frequent in young men and generally benign, with rapid resolution only through supportive care. Careful analysis indicates the benefit of vaccination outweighs the risk in all groups for whom the vaccine is recommended.

Jury Still Out on Convalescent Plasma

One year after the FDA issued an emergency use authorization, investigators are struggling to draw firm conclusions about the efficacy of this solution against COVID-19.

FDA Gives Full Approval to Pfizer’s COVID-19 Vaccine

A significant milestone in the ongoing battle against the pandemic.

Infectious Disease Alert Updates

California mandates COVID-19 vaccine for healthcare workers; Seasonal coronavirus in stem cell transplant

Adherence to the Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) Does Not Lead to Improved Clinical Outcomes

A longitudinal study from a single healthcare system found that adherence to the Medicare Severe Sepsis and Septic Shock Early Management Bundle resulted in some changes in process measures, but did not lead to improvements in clinical outcomes.

Treatment of Presumed Urinary Tract Infection in Afebrile Males: How Long Is Long Enough?

Symptom resolution after seven days of antibiotic therapy in afebrile males with presumed urinary tract infection was not inferior to 14 days of therapy.

COVID-19: Effective Post-Exposure Prophylaxis

Subcutaneous administration of a combination of anti-SARS-COV-2 antibodies effectively prevented COVID-19 in most household contacts of cases.

Updated Sexually Transmitted Infection Guidelines

The Centers for Disease Control and Prevention has updated their recommendations for the treatment of several sexually transmitted infections, including gonorrhea, trichomoniasis, bacterial vaginosis, pelvic inflammatory disease, and those due to Chlamydia trachomatis and Mycoplasma genitalium.

Neutrophil Extracellular Traps and COVID-19

Neutrophil extracellular traps (NETs) contribute to immune-mediated inflammation and thrombosis. Donor neutrophils were stimulated with plasma from patients hospitalized with COVID-19. R406 (metabolically active component of fostamatinib) abrogated release of NETs in vitro.

Children Hospitalized with SARS-CoV-2

Two recently published studies give a clear, consistent finding: About three-fourths of children hospitalized with SARS-CoV-2 do not have severe COVID-19-related illness but are merely identified as infected when subjected to screening tests. Surveys reporting the number or incidence of SARS-CoV-2-infected hospitalized children likely overestimate the actual burden of disease.