Infectious Disease
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Anti-parasitic Therapy of Chronic Chagas’ Cardiomyopathy
Two thousand eight hundred fifty-four patients with Chagas’ cardiomyopathy were randomized to benznidazole or placebo, were treated for up to 80 days, and were followed for a mean of 5.4 years. Trypanocidal treatment with benznidazole reduced serum parasite detection but did not reduce clinical cardiac deterioration.
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Oritavancin: Formulary Considerations
Oritavancin is a lipoglycopeptide bactericidal antibiotic for intravenous administration with activity against Gram-positive organisms, including methicillin-resistant Staphylococcus aureus.
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Acetaminophen for Fever in the ICU
Seven hundred ICU patients with fever and known or suspected infection were randomly assigned to receive acetaminophen 1 g IV or placebo every 6 hours until ICU discharge, resolution of fever, cessation of antimicrobial therapy, or death. Early administration of acetaminophen did not affect number of ICU-free days.
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Dual Combination ART with Cabotegravir and Rilpivirine Is Effective for Maintaining HIV Virological Suppression
Results of the phase 2 LATTE study show that after 24 weeks of induction triple therapy, maintenance therapy with cabotegravir (a long-acting dolutegravir analogue) and rilpivirine led to virological suppression in 82% of patients, compared to 71% who received efavirenz plus two NRTIs.
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Cutaneous Leishmaniasis in Syrian Refugees
Cutaneous leishmaniasis is spreading as refugees move from Syria through Turkey into Europe and throughout the world. Aware clinicians can consider diagnostic testing when facing unusual skin lesions in refugees.
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Xenotourism: Live Cell Therapy, Maybe Not So Therapeutic
ABSTRACT & COMMENTARY: Beware injection with sheep fetal cells.
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Clinical Briefs
In this section: improving cardiovascular outcomes through early treatment of diabetes; re-thinking PTSD treatment in veterans; and a link between rosacea and cardiovascular disease.
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Flibanserin Tablets (Addyi)
The FDA has approved the first drug for the treatment of hypoactive sexual desire disorder in women.
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The Impact of Hypoglycemia on Renal Impairment
A retrospective cohort study evaluated renal function data of 101 patients with type 2 diabetes and a history of severe hypoglycemia compared with a matched group of individuals with type 2 diabetes with no history of hypoglycemia.
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Efficacy and Safety of Very Early Mobilization After Onset of Acute Stroke
The higher dose, very early (within 24 hours) mobilization protocol was associated with a reduction in the odds of a favorable outcome at 3 months after stroke occurrence.