Infectious Disease General
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Infectious Disease Updates
Old Habits Die Hard, Especially with TB; Paxlovid: Is It Still Worth the Cost?
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Career Satisfaction and the Unmet Need for Infectious Disease Clinicians
There is a shortage of physicians in the United States, and many current physicians are considering reducing or ending their current clinical practices. Leading risk factors for discontinuing clinical work are taking fewer than 15 days of vacation each year, continuing to respond to electronic medical record inbox messages during vacation, and working more than 30 minutes per day during vacation.
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Moldy Bloodstream Infections
Bloodstream infections due to molds are uncommon, occurring predominantly in association with severe immunocompromise, even in the presence of anti-mold prophylaxis.
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Preventing Respiratory Syncytial Virus Illness in Infants
Prevention of respiratory syncytial virus (RSV) illness by using a monoclonal antibody, nirsevimab, in young infants entering the winter RSV season was recommended in 2023. Subsequently, effectiveness was evaluated in children in the northeastern United States. Nirsevimab was 68% effective in preventing RSV-associated need for medical care and 81% effective in preventing hospitalization for RSV-related illness.
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Antibiotics for Asymptomatic Bacteriuria: Using Urinalysis to Improve Stewardship
A cohort study found that in patients receiving antibiotics for a urinary tract infection, a urinalysis with pyuria and/or nitrituria identified 40% more cases of unnecessary antibiotic use compared to asymptomatic bacteriuria.
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Amoebic Encephalitis and Meningoencephalitis: It’s the Water
The Centers for Disease Control and Prevention investigated the cases of two patients: a child with meningoencephalitis due to Naegleria fowleri and a man with Acanthamoeba granulomatous encephalitis. Both were associated with exposure to water and both were fatal.
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Aztreonam and Avibactam for Injection (Emblaveo)
The U.S. Food and Drug Administration has approved a new combination antibiotic for the treatment of complicated intra-abdominal infections where there are limited or no alternative options.
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Infectious Disease Updates
COVID Monoclonals Needed for PrEP; Oral Camostat Ineffective in COVID-19; Mpox: Lessons Learned from Rio
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Cardiovascular Risk with mRNA COVID Vaccines
A large, nationwide population study in Sweden of the risk of adverse cardiovascular events after messenger ribonucleic acid (mRNA) COVID-19 vaccinations has shown that, except for rare cases of myopericarditis, severe cardiovascular events, such as myocardial infarction, heart failure, and stroke, are reduced, probably because of the prevention of COVID infection.
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Death Due to the ‘No Name’ Virus in Santa Fe
There is no specific treatment for hantavirus infection and no vaccine. Prevention consists of control and avoidance of rodents and their body fluids and excreta.