Infectious Disease General
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Malaria Management: From ACT to TACT
Artemisinin resistance of Plasmodium falciparum is expanding in Southeast Asia and in parts of Africa. Among older children and adults in West Africa, the addition of low-dose primaquine to standard artemisinin combination therapy successfully blocked gametocyte survival and parasite transmission.
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Measles Vaccination in Adults in 2025
The Centers for Disease Control and Prevention has updated measles vaccination recommendations.
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Shortages of Antimicrobial Agents
Shortages of antimicrobial drugs are frequent and represent a danger to patients and to public health.
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Infectious Disease Updates
Post-COVID Cryptococcosis — Even in Those Without Immunosuppression; Think Tularemia
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RSV Vaccination in Severely Immunocompromised Individuals
The antibody response to respiratory syncytial virus vaccination is significantly impaired in many severely immunocompromised individuals.
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Agreeing to Care for Unvaccinated Children
Many primary care clinicians choose not to enroll pediatric patients in their practices when the parents disagree with standard childhood immunization. However, such refusal to provide primary care raises significant controversy and ethical concerns.
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A Plasma Cell-Free DNA PCR Panel Test for Invasive Mold Disease
Lieu and colleagues performed a retrospective study of patients with suspected invasive mold disease that showed a high degree of concordance between noninvasive plasma cell-free deoxyribonucleic acid (DNA) polymerase chain reaction (PCR) testing and invasive specimen fungal test results.
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Clostridioides difficile Toxin Vaccine Failed to Prevent Primary Infection in Trial
A Phase III randomized clinical trial on adults 50 years of age and older found that a detoxified toxin A/B vaccine failed to reach its primary endpoint of preventing Clostridioides difficile infection. The vaccine was safe and well tolerated.
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Uncomplicated Pediatric Appendicitis: Antibiotics or Appendectomy?
Some patients with acute uncomplicated appendicitis do well with initial antibiotic treatment and do not require surgical appendectomy. However, as with adults, approximately one-third of antibiotic-treated children eventually will require surgical removal of the appendix despite the initial short-term success of medical management.
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Self-Testing for STIs Can Help Improve Access and Reduce Outbreaks
The increasing cases of syphilis, congenital syphilis, and some other sexually transmitted infections (STIs) in the post-pandemic era suggest clinicians and public health departments need additional strategies and tools to combat the problem.