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Mucormycosis Remains Highly Lethal

Mucormycosis continues to be associated with a high mortality rate. Polymerase chain reaction may speed diagnosis and allow earlier initiation of therapy. There appears to be no evidence supporting the use of combination as opposed to single agent (liposomal amphotericin B) therapy.

Outbreak of Marburg Virus Disease in Rwanda

A rising number of cases of Marburg virus disease, which is caused by one of the most virulent human pathogens, have been reported in Rwanda. Marburg virus infections in humans are rare but can present with a rapidly progressive febrile illness that can lead to multi-organ failure and shock with case-fatality rates of up to 80% to 90%.

Infectious Disease Updates

Managing Neurosyphilis; Combatting the Resurgence of Syphilis

Does Semaglutide Protect Against Adverse Effects from COVID-19?

Semaglutide recipients who developed COVID-19 had significant protection against the occurrence of adverse outcomes, including death.

Twice-Yearly Subcutaneous Lenacapavir Injection Prevents HIV Infection

Subcutaneous injection of lenacapavir every 26 weeks had 100% efficacy in preventing human immunodeficiency virus (HIV) infection in a high-risk population.

Viruses, Newborns, and Liver Failure

Neonatal liver failure due to herpesvirus infection is rare but can be severe. Herpes simplex virus 1 (HSV-1) is a more likely cause than HSV-2. Only about two-thirds of affected patients survive, despite recommended treatment with parenteral acyclovir.

Metformin Reduces SARS-CoV-2 Viral Load in Outpatients with COVID-19

A randomized, placebo-controlled clinical trial of outpatients with COVID-19 found that metformin reduced SARS-CoV-2 viral load 3.6-fold compared to placebo, while ivermectin and fluvoxamine showed no benefit.

The Rise of Oropouche Virus

Oropouche virus is an arthropod-borne virus that has been primarily endemic to the Amazon region. The incidence of Oropouche virus disease has significantly increased over the past few years, and recent outbreaks have been reported in areas without previous endemic transmission and have led to fatalities and vertical transmission resulting in adverse pregnancy outcomes.

Infectious Disease Alert Updates

Abandoning Universal COVID Admission Screening; Does Obesity Affect HIV Drug Levels? Eat Your Fruits and Vegetables!

Out of Africa Again? A New Version of Mpox

A novel mpox clade has emerged in Africa and has the potential for a global epidemic.