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Each year in the United States, a few isolated cases of plague are reported. This year, possibly because of increased spring rains leading to an increase in the rodent population, an unprecedented 13 cases of plagues have occurred in 4 states (New Mexico, California, Colorado, and Texas).
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Synopsis: In these 2 studies, the quadrivalent measles, mumps, rubella, and varicella (MMRV) vaccine, with increased potency of varicella compared to the current monovalent varicella vaccine, provides a varicella response rate of 81% and 91% after 1 dose, and 99% and 100% after 2 doses.
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The American Society for Microbiology Periodically publishes updates, called Cumitechs, to their recommendations regarding specific areas of clinical microbiology. The following is a brief summary, written primarily from a clinicians point of view, of their recent monograph on blood cultures. The recommendations, with the exception of the recommended volume of blood draws, apply to both children and adults.
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Synopsis: Clostridium difficile-associated disease (CDAD) is increasing in incidence and severity, and is appearing in patients even in the absence of recent hospitalization or antimicrobial use.
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Synopsis: The US Department of Health and Human Services (DHHS) periodically updates their guidelines for antiretroviral therapy. The latest iteration of these guidelines was published in October 2005.
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These authors report on the unique presentation of a 17-year-old previously healthy woman who developed acute onset fever, headache, nausea, and vomiting. Lumbar puncture confirmed a cerebrospinal fluid pleocytosis, and blood and CSF (but not urine) cultures yielded Group B streptococcus (S. agalactiae).
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Which Antipsychotics Are More Dangerous?; Should CPOE Undergo Evaluation?; New Treatment for Tennis Elbow; FDA Actions
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Synopsis: Investigators reported finding the presence of a metallo-â-lactamase gene mediating resistance to multiple â-lactam antibiotics, including carbapenems, among multiple species of Gram-negative pathogens isolated from a single hospital in Australia.
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ADEP I-6 have a complex ring structure. ADEP-I is the primary natural product (factor A). ADEP-1 has congeners that have been optimized for antibacterial activity, with the addition of 2 fluorides, to produce a difluoronated phenylalanine side chain.
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