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The laboratory group from the Pasteur Institute and inserm screened for CCR5 coding region polymorphisms in 3 groups of Vietnamese subjects, including 47 HIV-1 infected intravenous drug users (IDUs), 50 highly HIV-1 exposed but seronegative IDUs, and 37 HIV-1 unexposed seronegative individuals.
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Following the introduction of more highly active antiretroviral therapy in ~1995, epidemiologists observed a 50% decrease in rates of invasive pneumococcal disease in persons with HIV/AIDS.
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Shan and colleagues examined outcomes of 18 gastrointestinal surgery patients with invasive candidiasis who were treated preemptively based on clinical criteria from 1999 through 2002, and compared them to outcomes of 18 patients treated only on the basis of positive blood cultures or other unequivocal evidence of deep infection from 1995 through 1998.
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Treatment of Benign Prostatic Hyperplasia; Treatment of Osteoarthritis of the Knee; Refractory Asthma and TNFConnection?; FDA Actions
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The first article reports the results of an industry-sponsored clinical trial comparing TDF/ABC/3TC vs EFV/ABC/3TC in treatment-naïve patients. Three hundred forty patients were randomized. Baseline characteristics, including CD4 count and HIV RNA level were similar between the arms.
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Since the fda approval of moxifloxacin in December 1991 for the treatment of community-acquired pneumonia, sinusitis, acute bacterial exacerbation of chronic bronchitis, and uncomplicated skin/skin structure infections, its indications for use has been expanded to include the treatment of complicated skin/skin structure infections and complicated intra-abdominal infections.
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This study from a single diabetic foot clinic in France involved a retrospective chart review of patients who underwent surgical percutaneous bone biopsy with culture for microbiologic diagnosis of osteomyelitis. Patients included for study were those who had not received either local or systemic antibiotics for at least 4 weeks prior to cultures being obtained.
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In the autumn of 2001, construction workers in the Siaures Miestalis (Northern Town) section of Vilnius uncovered a mass grave containing several thousand neatly stacked skeletons, most in a fetal position.
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Beginning in 1995, a remarkably extensive blood culture protocol was established at Stanford University Hospital for use in patients with fever of unknown origin or suspected endocarditis. This included the use of an average of almost 90 mL of blood from patients obtained by several venipunctures.
