Infectious Disease Alert
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Chronic Low-Dose Corticosteroids and Infection Risk
The prolonged use of low-dose oral corticosteroids (including < 5 mg prednisone equivalent doses) in rheumatoid arthritis patients is associated with an increased risk of infection.
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Corticosteroid Bursts and Subsequent Sepsis
Short-term (< 14 days) administration of oral corticosteroids is associated with an increased risk of adverse events, including an approximately two-fold risk of sepsis.
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First There Was MIS-C, Now There Is MIS-A
Multisystem inflammatory syndrome in adults (MIS-A), similar to multisystem inflammatory syndrome in children (MIS-C), is described by the Centers for Disease Control and Prevention.
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Ethical Issues Affecting COVID-19 Vaccination
The world waits eagerly for a COVID-19 vaccine. But the supply of vaccine is unlikely to initially meet the demand. Ethical issues are important as individuals and groups are prioritized for early vaccination.
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Infectious Disease Alert Updates
IL-6 Inhibition and Liver Failure; Can Chopsticks Make You Sick?
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Vitamin C, Thiamine, and Steroids for Septic Shock — Still Unproven
Combination treatment with ascorbic acid (vitamin C), thiamine (vitamin B1), and corticosteroids does not improve clinical outcomes in adults with septic shock.
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Biofilm, Tap Water, and a Nosocomial Mycobacterium abscessus Outbreak — Bring on the Sterile Water
Stopping a nosocomial Mycobacterium abscessus outbreak by eschewing tap water.
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Possible Aerosol Spread of SARS-CoV-2 in an Apartment Building
Although not definitive, evidence is consistent with aerosol spread of SARS-CoV-2 in an apartment building as a result of transport through the drainage system to apartments directly above.
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Four Months of Rifampin Is Just as Effective, Safer, and Less Expensive than Nine Months of Isoniazid for Latent Tuberculosis
A health system cost comparison found that four months of rifampin was safer and less expensive than nine months of isoniazid in high-income countries, medium-income countries, and African countries.
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Antibiotic Use in COVID-19 Patients
Fifty-seven percent of patients with COVID-19 infection treated at 38 hospitals in Michigan received early empiric antibiotics, although only 3.5% of patients had documented community-onset bacterial co-infection.