Infectious Disease Alert
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Oral Moxifloxacin vs. Intravenous Ertapenem Followed by Oral Levofloxacin and Metronidazole for Acute Appendicitis
A randomized controlled clinical trial found that a seven-day course of oral moxifloxacin was not noninferior to two days of intravenous ertapenem followed by five days of levofloxacin and metronidazole in adults with uncomplicated acute appendicitis.
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Unexpected Pediatric Benefits of the COVID-19 Pandemic
Despite the global tragedy of the COVID-19 pandemic, clinical experience suggests that there also have been some favorable indirect effects of pandemic-induced lockdowns on pediatric health. Specifically, there are lower rates of unscheduled primary care visits, emergency department visits, and hospitalizations for medical problems – without an increase in incompletely managed serious diseases.
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Getting to the Super Bowl: Lessons from the NFL on Controlling COVID-19
Aggressive implementation of mitigation procedures with continual evaluations and adjustments allowed the National Football League to complete their season with minimal COVID-19 transmission.
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Virus, Variants, Vaccines
The emergence of SARS-CoV-2 variants may compromise the efficacy of current vaccines.
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Infectious Disease Alert Updates
Excess Deaths During COVID-19; Subclinical Influenza Infection in Healthcare Workers; Compression Garments Effective in Reducing Cellulitis
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Neurotropism of COVID-19: What Is New?
SARS-CoV-2 may gain access to the brain via the olfactory epithelium. The olfactory epithelium and bulbs may serve as an entry point for SARS-CoV-2 infection into the central nervous system.
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Does the Addition of IV Metronidazole Improve Outcomes of Severe Clostridioides difficile Infection?
These studies indicate that the addition of intravenously administered metronidazole in the treatment of severe Clostridioides difficile infection is unwarranted.
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Malaria and Anemia — Chemoprophylaxis Helps
For young children in Africa who return home after hospitalization for severe anemia, monthly long-acting malaria prophylaxis can reduce the rates of readmission and death during the three months following hospitalization.
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Candidemia in the United States
Candidemia, a common bloodstream infection in the United States, is associated with high mortality. There is concern about increasing resistance to antifungals.
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Healthcare Workers with Antibody to SARS-CoV-2 Have Strong Protection Against Reinfection
A study of healthcare workers demonstrated that the presence of antibody to SARS-CoV-2 spike protein or to nucleocapsid provides strong protection against infection with this virus for up to six months.