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Self-reported personal history of endometriosis was associated with an increased risk of ovarian cancer. Further, it was differentially associated with clear cell, endometrioid, and low-grade serous ovarian carcinoma in this pooled analysis. No relationship appeared between endometriosis and high-grade serous or mucinous ovarian cancer, or borderline variants of these two histologies. The results suggest further work is necessary to understand whether endometriosis plays a strategic precursor role in certain ovarian cancer histological subtypes.
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There has been much written about the salutary effects of moderate alcohol consumption in reference to a number of non-malignant chronic diseases. The effects on cancer in general are less compelling. However, in the current meta-analysis examining alcohol consumption and the development of renal cell carcinoma, a protective effect for light and moderate drinkers is clearly demonstrated. This protective effect is in the 10-20% range.
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Side effects of statins; effects of cannabis use; antihypertensives and lip cancer; and FDA actions.
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Preclinical studies provide a rationale for examining a role for sunitinib in the treatment of breast cancer. However, in this large, multicenter trial, the combination of sunitinib with docetaxel did not prolong progression-free or overall survival when compared to docetaxel alone, and it appeared to be less well tolerated. The role for sunitinib remains to be established for the treatment of breast cancer.
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The purpose of this article was to provide a systematic review and critical appraisal of the literature on the incidence and risk factors for unplanned endotracheal extubations, factors associated with reintubations, and outcomes of unplanned extubations. Several evidence-based recommendations were presented to prevent unplanned extubations.
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In the ICU at the University of Connecticut Health Center, adult patients with both medical and surgical problems are primarily managed by the same team of intensivists.
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A middle-aged man with community-acquired pneumonia complicated by underlying cardiomyopathy develops the acute respiratory distress syndrome (ARDS).
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This randomized Phase 3 clinical trial found that adding cetuximab to standard mFOLFOX6 adjuvant chemotherapy did not improve either overall survival or disease-free survival in patients with resected stage III colon cancer, including those with wild-type KRAS tumors.
