Hematology/Oncology General
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Avutometinib Capsules and Defactinib Tablets (Avmapki Fakzynja CO-PACK)
The U.S. Food and Drug Administration has granted accelerated approval for a combination of two kinase inhibitors, avutometinib and defactinib, for the treatment of KRAS-mutated recurrent low-grade serous ovarian cancer who have received prior systemic therapy, including a platinum-based regimen.
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Revumenib Tablets (Revuforj)
The U.S. Food and Drug Administration has approved the first menin inhibitor, revumenib, for the treatment of relapsing or refractory acute leukemia with a lysine methyltransferase 2A gene (also known as the mixed lineage leukemia gene) translocation in adults and pediatric patients.
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Long-Term Proton Pump Inhibitor Use and the Risk of Colorectal Cancer
A large retrospective cohort study demonstrated that long-term use of proton pump inhibitors is associated with an increased risk of developing colorectal adenocarcinoma.
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Pediatric Hematologic Emergencies
Hematology is a challenging area in pediatrics, with unique diseases that do not occur commonly. The authors review critical pediatric hematologic conditions that the acute care provider may encounter and provide a concise guide to diagnosis, stabilization, and management.
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Updated Recommendations on Pediatric End-of-Life Care
A report includes a review of essential elements of care for patients and families. The authors covered discussions on goals of care, how to establish end-of-life care goals, advance care planning, and palliative and hospice involvement.
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Betibeglogene Autotemcel Suspension (Zynteglo)
The FDA has approved the first cell-based gene therapy to treat adult and pediatric patients with beta-thalassemia who require regular blood transfusions.
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Parents, IRBs Hold Different Views on Phase I Pediatric Oncology Trials
IRB members are more likely than the public to think the risks outweigh the potential medical benefits. Parents think about the possibility of caring for a child with severe cancer and no treatment alternatives. IRBs ensure trials are ethical and that pediatric subjects are not exposed to excessive risk.
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Analysis Reveals More About Claims Denials Tied to ACA Marketplace Plans
Meanwhile, evidence mounts indicating access to proper insurance coverage leads to better cancer outcomes.
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The Association Between Cancer Mortality and Physical Activity for Middle-Aged and Older Patients
In a prospective cohort study of 8,002 middle-age and older Black and white adults in the United States, replacing sedentary behavior with physical activity was associated with a lower cancer mortality risk.
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Can Left Ventricular Strain Detect Early Cardiac Toxicity of Cancer Chemotherapy?
Using left ventricular peak systolic global longitudinal strain vs. left ventricular ejection fraction to survey patients undergoing potentially cardiotoxic chemotherapy with at least one other risk factor for heart failure showed no difference in the primary endpoint of the difference in ejection fraction between the two groups at one year.