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  • Medicine Compliance and Survival in Heart Failure

    The current polypharmacy management approach to chronic heart failure due to systolic dysfunction is of concern because it may lead to noncompliance
  • Percutaneous Aortic Valve Replacement

    Surgical aortic valve replacement (avr) remains the gold standard treatment for patients with severe aortic stenosis (AS). However, a number of patients are at increased risk of mortality during AVR due to advanced age or co-morbidities.
  • Detection of Diastolic Dysfunction

    Heart failure with normal left ventricular (LV) systolic function is thought to be due to diastolic dysfunction in most cases, but confirming LV diastolic dysfunction by echo Doppler techniques is often challenging.
  • Weekly Statins

    These investigators describe the results of once a week rosuvastatin in 10 patients intolerant to once-a-day statins due to myalgias, high liver function tests and gastrointestinal side effects.
  • Clinical Briefs By Louis Kuritzky, MD

    Meta-analysis (META) is intended to provide greater strength of evidence by combining like populations of similar clinical trials in similar circumstances. Unfortunately, no two populations or sets of circumstances are identical, resulting in conclusions being drawn from large data sets which may not be reliable.
  • When Diets Fail...

    Compared with morbidly obese individuals who did not have surgery, those who underwent gastric bypass surgery had reduced total mortality after about 7 years, especially for deaths from diabetes, heart disease, and cancer. However, the rate of death from accidents and suicides was higher in the surgery group than in the control group.
  • Should Triglyceride Blood Levels be Measured in the Fasting State?

    Elevated non-fasting triglyceride levels are associated with incident cardiovascular events independent of traditional cardiac risk factors, levels of other lipids, and markers of insulin resistance; by contrast, fasting triglyceride levels demonstrated little independent relationship to these events.
  • Paroxysmal Atrial Fibrillation: An Underdiagnosed Cause of Stroke?

    Frequent atrial premature beats predict paroxysmal atrial fibrillation in stroke patients: An opportunity for a new diagnostic strategy.
  • Maraviroc Tablets (Selzentry™)

    The FDA has approved the first of a new class of anti-HIV drugs. Maraviroc is a selective CCR5 co-receptor antagonist.
  • Pediatric Malignancies Masquerading as Infections

    Among 561 patients diagnosed with malignancy from 1993-2003 in the Northern Alberta Childrens Cancer Program, infectious diseases consultation was initially requested for 21 children (<15 years of age) a median of 7 days (range, 0-32 days) prior to definitive diagnosis.