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Since the risk of gastrointestinal bleeding is increased when clopidogrel is added to aspirin therapy in patients with acute coronary syndromes (ACS), many prescribe proton-pump inhibitors (PPIs) to reduce this risk. However, mechanistic studies suggest that PPIs may reduce the effectiveness of clopidogrel.
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Dr. George Dourgas presented the results of the Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction (HORIZONS AMI) analysis of predictors of stent thrombosis in more than 3,600 patients, and showed that higher doses of clopidogrel (600 mg) pharmacologic therapy, lesion characteristics, and the length of stents were predictors of early-stent thrombosis.
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The introduction of drug-eluting stents (DES) was met with enthusiasm from the interventional cardiology community because of the dramatic reduction in rates of in-stent restenosis (ISR). However, it came to be recognized that this clinical benefit, due to reduced proliferation of smooth muscle cells, came at a price.
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Dual anti-platelet therapy with aspirin and clopidogrel reduces cardiac events in patients who have acute coronary syndromes (ACS) and in patients who have percutaneous coronary intervention (PCI). Recently, the phenomenon of "clopidogrel resistance" has received much attention because of the clinical problems of stent thrombosis and recurrent ACS. However, a precise definition of this clinical entity is lacking.
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This report from the implantable cardioverter defibrillator (ICD) portion of the National Cardiovascular Data Registry focuses on the relationships of gender to in-hospital, ICD-associated adverse events.
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Aspirin dose and cardioprotection; uncovering modafinil's abuse potential; proton-pump inhibitors and clopidogrel; FDA actions.
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The U.S. National Registry of Sudden Death in Athletes assembles and analyzes data on the deaths of young athletes who participate in competitive sports.
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Many reports evaluating coronary risk factors in overtly healthy individuals have been highlighted in a variety of preventative cardiology programs, guidelines, and sources. The Framingham Study gave an amazingly powerful kick start to the recognition of coronary risk factors.
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Patients with lyme arthritis were more likely to have knee involvement (p < 0.001), a history of a tick bite (p = 0.02), and less likely to have a history of fever (p < 0.001) or fever ...
