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The clinical features of CADASIL vary depending on the specific mutation that is present in the NOTCH3 gene.
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Aspirin dose and cardioprotection; uncovering modafinil's abuse potential; proton-pump inhibitors and clopidogrel; FDA actions.
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In the first non-randomized trial of Quinacrine for the treatment of prion diseases, there was no benefit in terms of survival or neurological outcome.
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Inclusion body myositis remains a mystery the underlying cause and pathogenesis have yet to be fully understood.
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The authors in this retrospective study review their experience in long term EEG monitoring (LTM) and utility in the clinical diagnosis and classification of epilepsy.
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Surveillance data from the CDC show that central-line associated bloodstream infections due to methicillin-resistant Staphylococcus aureus in U.S. intensive care units showed an overall decrease of 50% during 1997-2007.
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Dronedarone is a new antiarrhythmic drug with structural similarities to amiodarone. During development of the molecule, the steps included removal of the iodine atoms and making the compound more lipophilic; the latter produces a shorter elimination half-life and reduced tissue accumulation.
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In this study of physician use of clinical information technology in relation to 4 common diagnoses in 41 urban hospitals in Texas, inpatient outcomes were better the more extensive the use of computerized order entry, test results, physician charting, and decision support. Increased use of IT was also associated with significantly lower costs for all hospital admissions.
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Whether oral vitamin K reduces the risk of bleeding related to excessive anticoagulation from warfarin remains unclear.
