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The antiplatelet effect of clopidogrel is dependent upon its conversion and activation through the 2C19 pathway of the P450 system. Blockade of this pathway occurs because of genetics, in persons who do not have sufficiently active 2C19, and pharmacotherapies that specifically block 2C19. Proton pump inhibitors (PPIs), particularly omeprazole, are recognized to be 2C19 inhibitors. Is there reason for concern?
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The ECG shown above was obtained from a 72-year-old woman as a baseline. How would you interpret her ECG? How many blocked and early findings can you identify?
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The FDA has approved the first treatment for relapsed or refractory peripheral T-cell lymphoma. Pralatrexate, an inhibitor of dihydrofolate reductase, was granted accelerated approval by the FDA. It will be marketed by Allos Therapeutics as Folotyn™.
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The relationship of FPG and A1c to diabetic retinopathy; Getting the most bang for your buck with lipid measurement; Nortriptyline, gabapentin, or both for neuropathic pain; Which insulin regimen for type 2 diabetes; Cardioprotective effects of ACE inhibitors in African American men; Missed opportunity: Aldosterone antagonists in heart failure
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During the week ending October 31, 2009, 7.4% of all deaths in the United States reported to the CDC were due to pneumonia and influenza and > 99% of all subtyped influenza A viruses were 2009 influenza A H1N1 viruses.
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It has been known for decades that influenza viruses have a propensity to affect muscle. Muscle aches from mild to severe occur regularly with the acute attack of the virus.
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Blood was drawn from healthy individuals living in Toronto with normal hemoglobins and from donors who were known to have protein kinase deficiency (PKD), G6PD deficiency, and Beta thalassemia.
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In this study, 77,047 participants from the U.S. Department of Defense prospective Millenium Cohort Study were enrolled in 2001; 55,021 underwent follow-up screening in 2004-2006.
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A study of vertical transmission of Hepatitis B virus (HBV) was conducted among 2,365 pregnant women in Germany who were negative for HBV surface antigen (HBsAg).
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Various strains of human influenza virus can infect other mammalian species.
