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In this issue: Efficacy of once-daily insulin, aldo-sterone use in heart failure, erectile dysfunction Clinical Practice Guidelines, and FDA Actions.
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A prospective, multi-center, double-blind, placebo-controlled, randomized trial of daily trimethoprim-sulfamethoxazole (TMP-SMZ; 2 mg TMP and 10 mg SMZ per kg) vs. placebo was conducted in four centers in Australia during 1998-2007 among children birth to 18 years of age with a history of at least one symptomatic, culture-proven urinary tract infection.
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Many clinical trials have confirmed the benefit of early invasive therapy for high-risk patients presenting with acute coronary syndromes (ACS). However, the optimal timing of cardiac catheterization in this group remains unknown.
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This retrospective cohort study reaffirms the link between hyperglycemia and mortality in the ICU, but demonstrates that the risk does not apply equally to all patient groups and, instead, varies based on admission diagnosis.
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Recombinant Panton-Valentine leukocidin (PVL) toxins showed lytic activity against human (but not murine) neutrophils. The lytic activity of culture supernatants of USA400 and USA300 strains of MRSA were completely neutralized by anti-PVL monoclonal antibodies. In contrast, phenol-soluble modulin alpha3 (PSM) failed to lyse human neutrophils but did enhance PVL-mediated neutrophil lysis.
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Dabigatran etexilate is an oral compound that is converted after absorption by a serum esterase to dabigatran, a direct competitive inhibitor of thrombin.
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Current indications for cardiac-resynchronization therapy (CRT) require that patients have New York Heart Association (NYHA) Class III or Class IV heart-failure symptoms.
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The Guttmacher Institute, in collaboration with the World Health Organization, recently published an updated account of abortion rates worldwide.
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It is not a great mystery that primary ovarian cancer, when presenting with metastatic intra-abdominal and/or extra-abdominal disease, represents a formidable therapeutic challenge, as these women are usually highly symptomatic, frequently of poor nutrition, and in need of aggressive dual modality therapy: surgery and chemotherapy.
