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Steroids for Severe Community-Acquired Pneumonia: More Evidence or More Uncertainty?
Community-acquired pneumonia (CAP) is the leading cause of mortality from infection in industrialized countries, and treatment failure occurs in 10-20% of cases despite appropriate antibiotic therapy. Thus, effective treatment strategies that reduce the burden of CAP would have a major impact on public health. Several previous studies that investigated the role of corticosteroids in CAP produced mixed results. Torres and colleagues hypothesized that corticosteroids modulate the immune response in severe CAP, thereby decreasing treatment failure.
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Effects of Lifestyle Modifications on the Coronary and Carotid Atherosclerotic Burden
A look at how lifestyle changes, including dietary modifications and regular exercise, impact therapy for atherosclerotic cardiovascular disease.
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Diet Sodas: Are They Really Diet?
Over the past several decades, concerns about increased sugar consumption has led some experts to recommend the use of non-nutritive sweeteners (NNSs).1
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No Link Between MMR and Autism
In this issue: Prevention of Type 1 Diabetes in Children; Early Initiation of HPV Vaccine; Effects of Antibiotic Exposure Early in Life; ED-initiated Buprenorphine for Opioid-dependent Patients; and FDA Actions.
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Roflumilast for Acute Exacerbations in COPD
Acute exacerbations of COPD are potentially highly consequential: in-hospital mortality is approximately 10%, and up to 25% of patients admitted to the ICU die.
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Clindamycin vs TMP-SMX for Skin Infections
The treatment of cellulitis, with or without a local abscess, has become more complicated since MRSA has assumed the causal role of “guilty until proven otherwise” in such settings.
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Ongoing Saga of Homocysteine and Vasculopathy
The relationship between homocysteine and vascular disease has been recognized for at least two decades. Indeed, the strength of the association between plasma hCYS levels and coronary atherosclerosis surpasses that of cholesterol.
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Treatment of OSA Reduces Risk of Repeat Revascularization After PCI
Obstructive sleep apnea is associated with numerous comorbidities and downstream consequences, not the least of which are increased cardiovascular events, hypertension, and arrhythmias.
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Difficult Questions About Testosterone and Mortality
The number of men receiving treatment for hypogonadism has increased dramatically over the past decade. At the same time, some clinical trials have suggested that there are safety issues with testosterone.
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Psoriasis Is Associated with Insulin Resistance
The pathophysiology of psoriasis has much in common with rheumatoid arthritis.