Clinical
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FDA Approves Ivabradine for Systolic Heart Failure
ABSTRACT & COMMENTARY: In HF patients with a heart rate above 70 bpm, despite truly maximum-tolerated doses of beta-blockers, ivabradine is an option.
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Ivabradine Tablets (Corlanor ®)
Ivabradine's effect in reducing heart rate, by acting on the SA node, was most prominent at a higher heart rate, thus minimizing the risk of bradycardia.
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Clindamycin vs. Trimethoprim-Sulfamethoxazole for Uncomplicated Skin Infections
Cure rates did not differ between the treatments and rates of adverse events were similar in the two groups.
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Utility of the New Cholesterol Guidelines
The risk:benefit ratio is much better for moderate- than high-intensity statins.
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Risk of NSAID Use in Patients Receiving Antithrombotic Therapy After Myocardial Infarction
The use of NSAIDs was associated with increased risk of bleeding and excess thrombotic events, even after short-term treatment.
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Infectious Disease Alert Updates
Surprise! My Kid Has Chlamydia; More on C. diff. Transmission; Staph. aureus Carriage and Moustaches
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Treatment of Invasive Aspergillosis: Are Two Drugs Better Than One?
Although potential benefit may have been detected in a post hoc subset analysis, the addition of anidulafungin in the initial phase of primary treatment of suspected or documented invasive aspergillosis was not associated with a significant improvement in survival.
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Nasal Screening for MRSA: The New Basis for De-escalation of Empiric Antibiotics?
The high negative predictive value of a negative nasal screen for methicillin-resistant Staphylococcus aureus suggests these patients do not have lower respiratory tract infections caused by the organism.
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Initial Antiretroviral Regimens — New Recommendations
Four of the five recommended initial antiretroviral regimens in treatment-naïve adolescents and adults are based on integrase strand transfer inhibitors.
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Lung Ultrasound to Diagnose Pneumonia in Children
Whether based on history, tachypnea, or X-ray findings, the diagnosis of pneumonia in children is incompletely accurate. Ultrasound is a reasonable alternative tool for the diagnosis of childhood pneumonia.