Clinical
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Early Benefits of HPV Vaccination
A large study of HPV vaccination among girls 13-14 years of age demonstrated significant reduction of cervical dysplasia that was detectable by 17 years of age, providing justification for not delaying HPV vaccination in girls until older adolescence.
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Early, Goal-directed Therapy of Septic Shock
ABSTRACT & COMMENTARY: Hemodynamic management did not lead to an improvement in outcome.
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Hospital Wards with Higher Rates of Antibiotic Prescribing Are Associated with Increased Risk for C. difficile Infection
A retrospective observational study found that among hospitalized patients, ward-level antibiotic prescribing was associated with a significantly increased risk for C. difficile infection beyond what would be expected with patient-level antibiotic use.
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Severe Alcoholic Hepatitis: Prednisolone or Pentoxifylline?
ABSTRACT & COMMENTARY: A clinical trial studied short- and medium-term mortality in patients admitted to the hospital for severe alcoholic hepatitis.
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Macrosomia
Previous Alerts have touched on the relationship between big babies and big problems, such as birth injury, infant/childhood obesity, and diabetes. This special feature is designed to provide a more comprehensive look at the causes, risks, prediction, management, and prevention of macrosomia.
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Mammograms: The Cost of Overdiagnosis
In the United States, the costs associated with the management of false-positive mammograms and breast cancer overdiagnosis is estimated to be $4 billion each year.
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Are We Ready to Give Up the Pap Smear?
A review of the ATHENA trial, which evaluated the prevalence of hrHPV in a large cohort of women and evaluated the most sensitive screening strategy.
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Isotretinoin and Contraception: Should iPLEDGE Be Changed?
In this study of female dermatologic patients, knowledge of the typical effectiveness of contraceptive methods increased after viewing a simple information sheet. Given the teratogenicity of isotretinoin, expanding the use of highly effective contraceptive methods among women of child-bearing potential using this medication is essential.
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Wide Tachycardia in a Patient with Chest Pain
The 12-lead ECG and accompanying long lead II rhythm strip in the Figure was obtained from a 70-year-old woman with chest pain. She was hemodynamically stable at the time this ECG was recorded. What is the rhythm? -
Clinical Briefs
Accumulation of briefs: Consequences of NSAID Use in Patients Receiving Post-MI Antithrombotic Prophylaxis, Psoriasis Is Associated with Insulin Resistance, and Difficult Questions About Testosterone and Mortality