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Non-Ischemic Forearm Exercise Testing for McArdle’s Disease
Traditionally, the ischemic forearm exercise test has been used to help in the diagnosis of glycogen storage diseases of muscle, but this test is fraught with dangerous complications. A non-ischemic forearm test has been proven to be highly sensitive and specific, with minimal side effects, and should replace the traditional test.
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Repetitive Transcranial Magnetic Stimulation for Treatment of Parkinson’s Disease
In several randomized, sham-controlled trials, repetitive transcranial magnetic stimulation was shown to be effective in reducing the motor manifestations of Parkinson’s disease, with minimal side effects.
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Linking Traumatic Brain Injury and Parkinson’s Disease: The Evidence Builds
A retrospective study based on an administrative database compared more than 50,000 admissions with traumatic brain injury (TBI) with more than 100,000 admissions for other traumatic injury, and found that TBI in individuals older than 55 years of age led to a 44% increased risk of developing Parkinson’s disease in the ensuing 5-7 years.
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REM Behavior Disorder — A Unique Window into the Mysteries of Neurodegenerative Disease
REM behavior disorder may precede α-synucleinopathies by decades and may be a biomarker of future disease.
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Clinical Briefs
This article covers the following topics: the saga of homocysteine and vasculopathy; roflumilast for acute exacerbations in COPD; and treatment of OSA reduces risk of repeat revascularization after PCI.
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Insights into the Association of Atrial Fibrillation and Myocardial Infarction
Given the mounting evidence suggesting that stroke, MI, and AF have pathophysiologic mechanisms in common, the presence of any one should at a minimum heighten suspicion for the others.
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The Echo Calcium Score
Aortic valve sclerosis and mitral annular calcification detected by echocardiography are known to be associated with atherosclerosis and are predictive of cardiovascular morbidity and mortality.
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Antibiotic Prophylaxis Guidelines and Endocarditis Rates
Despite the limitations of this type of study, it supports the U.S. view of treating high-risk patients with antibiotic prophylaxis.
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Endovascular Intervention Takes Center Stage in Treatment of Acute Stroke
Two studies join a growing body of recent evidence supporting improved clinical outcomes with interventional treatment of acute stroke.
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Valve Thrombosis After TAVR: Is It as Rare as We Thought?
A CT study demonstrates that valve thrombosis may be more common than earlier thought.