Clinical
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Potential Benefits of Down Titration Through Inhaled Steroid Discontinuation
The likelihood of serious pneumonia was reduced by 37% in patients who discontinued inhaled corticosteroids vs those who did not.
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Prostate Cancer Screening: Have Clinicians Been Listening?
Published modeling methods suggest an increase in prostate cancer mortality by omission of universal screening; to date, that has not been the case, but may require a longer window of observation before reaching definitive conclusions.
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Vitamin D: Conclusions From an NIH Conference
Observational studies indicate that low vitamin D status is associated with risk for cardiovascular disease, cancer, diabetes, and other important disorders, but whether this relationship is causal is not yet known, and whether correction of such a causal relationship (if established) will improve outcomes remains to be determined.
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Good Cardiovascular News from the SGLT2 Inhibitor Class?
The widely celebrated results of a recent landmark trial give at least one physician reasons to pause.
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Spironolactone Best Add-on for Resistant Hypertension
Spironolactone provided statistically significant greater reductions in blood pressure than two other active agents.
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ECG Review: Why are aVR Waveforms Positive?
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Clinical Briefs
In this section: Are annual physicals worth it?; breakfast might be the most important meal of the day; and evaluating the total knee replacement. -
Insulin Degludec Injection (Tresiba)
Insulin degludec provides an alternative to insulin glargine and insulin detemir as long-acting human insulin analogs.
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Beta-blocker Dose More Important Than Heart Rate in Systolic Heart Failure
In chronic heart failure with reduced ejection fraction, titrating beta-blocker doses may confer a greater benefit than reducing heart rate.
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Using Procalcitonin to Differentiate Bacterial from Viral Meningitis
A meta-analysis based on nine studies found an elevated serum procalcitonin to be an accurate test for differentiating bacterial from viral meningitis in adults.