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Factor V Leiden Mutation and Combined Hormonal Contraception? Is Thrombosis Risk Acceptable?
A meta-analysis of cohort studies supports that women with mild thrombophilias like heterozygote Factor V Leiden mutation can use combined hormonal contraception if other reliable methods are not acceptable.
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Preterm Premature Rupture of Membranes: When to Deliver?
A recent large multicenter, randomized clinical trial has shown that delivering patients with premature preterm rupture of membranes at 34 weeks, rather than pursuing a watchful waiting approach until 37 weeks, does not afford greater protection against neonatal sepsis.
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FDA Actions
In this section: The FDA approves new chronic hepatitis C treatment, greenlights a treatment course for primary biliary cirrhosis, and strengthens warning about the risk of acute kidney injury in several diabetes medications.
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Patients Need More Education on Opioid Storage, Disposal
Recent survey discovers troubling trends.
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Good News for Type 2 Diabetics
The rate of the first occurrence of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke among patients with type 2 diabetes mellitus was lower with liraglutide than with placebo.
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Drug May Slow Renal Disease Progression
In patients with type 2 diabetes at high cardiovascular risk, empagliflozin was associated with slower progression of kidney disease and lower rates of clinically relevant renal events than was placebo when added to standard care.
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Safe, Effective Alternatives to Warfarin
Non-vitamin K antagonist oral anticoagulants are safe and effective alternatives to warfarin in the routine care setting.
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CDC Advisory Committee Recommends Against Live Attenuated Influenza Vaccine
The decision came after a committee reviewed data showing vaccine effectiveness for the live attenuated influenza vaccine of only 3%.
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Cocaine Use and Pyoderma Gangrenosum
In addition to the other obvious concerns about cocaine use, add pyoderma gangrenosum to the list.
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Considering Perioperative Statins in Cardiac Surgery
Despite early data suggesting benefits of perioperative statin treatment, a larger data set fails to confirm benefit and indicates some potential harm.