Clinical
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Delaying Intubation in Severe Alcohol Withdrawal
Delaying intubation until aspiration or cardiopulmonary decompensation did not affect mortality but increased the incidence of pneumonia and length of stay. -
Cerebral Microbleeds Are Risk Factor for Symptomatic Intracerebral Hemorrhage in Patients Undergoing IV Thrombolysis
Cerebral microbleeds, as visualized on gradient-echo or susceptibility-weighted MRI, are considered markers of bleeding-prone cerebral microvessels and constitute a significant and independent predictor of future intracerebral hemorrhage.
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Which Patients with TIA Are at High Risk for a Recurrent Cerebral Vascular Events?
Recurrent cerebral vascular events are one of the main determinants of outcome in patients after minor strokes and transient ischemic attacks.
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Dual Antiplatelet Therapy Appears More Effective Than Single Therapy
How long should duel antiplatelet therapy after stroke or transient ischemic attack last?
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Epidemiology of Neuromyelitis Optica Spectrum Disorders in Two Distinct Populations: Black and White
Based on an epidemiological study in two ethnically and geographically distinct populations of patients diagnosed with central nervous system inflammatory demyelinating diseases, the authors report a higher prevalence among Afro-Caribbean patients in Martinique in the eastern Caribbean sea vs. a predominantly Caucasian population in Olmstead County in Minnesota. The study demonstrates a propensity for neuromyelitis optica to affect blacks more than Caucasians.
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Blood-Based Biomarkers in the Evaluation of Alzheimer’s Disease
At the present time, no blood-based biomarkers have been identified as reliable indicators of A-beta amyloid deposition in the brain.
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Greater Weight Loss Later in Life Is Associated with Increased Risk of Mild Cognitive Impairment
In a population-based, prospective study of subjects 70 years of age or older, increasing weight loss per decade from midlife to late-life was associated with an increased risk of incident mild cognitive impairment.
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Do Miller Fisher Syndrome, Guillain-Barré Syndrome, and Bickerstaff Encephalitis Overlap?
All three of these syndromes — Miller Fisher, Guillain-Barré, and Bickerstaff encephalitis — occur following an acute gastrointestinal infection, with many cases of overlap syndromes, and deficits may progress during the first few days of illness.
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Treatment of Glioblastoma in Elderly Patients
In a retrospective cohort study of elderly patients with glioblastoma, overall survival was superior with combined-modality therapy (radiation and chemotherapy) compared with chemotherapy alone or radiation alone.
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Effect of Antibiotic Resistance on Prevention of Surgical Site Infections
This interesting article from Teillant and colleagues (who is now doing some interesting work at the Center for Disease Dynamics, Economics, and Policy in Washington, DC) highlights the threat of antibacterial resistance not only to our ability to fight active infection, but to prevent surgical site infection using perioperative antibacterials.