Clinical
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Distinct EEG Features May Help Prognostication of Patients with Early PAMM
Early post-anoxic multifocal myoclonus (PAMM) traditionally has been considered a grave prognostic feature in patients who remain comatose after cardiac arrest. This study defines distinct electrographic phenotypes in the setting of PAMM with substantially different prognostic outcomes.
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Functional MRI in REM Behavior Disorder Is Suggestive of Future Parkinson’s Disease
Rapid eye movement behavior disorder carries an increased risk of future Parkinson’s disease and has fMRI and DaTSCAN features that are similar to those in patients with Parkinson’s disease.
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Association of Traumatic Brain Injury with Late-life Neurodegenerative Diseases
This study analyzed pooled clinical and neuropathological data of older adults free of dementia from three prospective cohort studies and found that traumatic brain injury with loss of consciousness was associated with risk for Lewy body accumulation, Parkinson’s disease, and progression of Parkinsonism, but not dementia, Alzheimer’s disease, neuritic plaques, or neurofibrillary tangles.
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Neuropathy in Myeloma
Peripheral neuropathy is uncommon at presentation in patients with myeloma, and may be complicated by vitamin D deficiency and the neurotoxic effects of chemotherapy.
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Impulse Control Disorders in Parkinson’s: Are All Dopamine Agonists Equal Offenders?
This observational study of 425 patients with a broad range of stages of Parkinson’s disease found that long-acting pramipexole and transdermal rotigotine were less likely to be associated with impulse control disorders than were immediate-release pramipexole and any formulation of ropinirole. This study highlights differences between dopamine agonists that may affect patient care.
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Dietary Supplement Safety
A recent ABC article on a Consumer Reports publication reviewed concerns surrounding dietary supplement safety.
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Add Fat to the Mediterranean Diet? Some Benefits Found
Studies examining the Mediterranean diet with unrestricted fat intake find benefits on cardiovascular disease, diabetes, and breast cancer risk.
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Chocolate Counteracts the Effects of Sleep Deprivation
An acute administration of a chocolate rich in flavanols (a subclass of flavonoids) was found to mitigate the cardiovascular and cognitive effects of sleep deprivation in a group of young and healthy individuals.
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Incretin and Insulin Secretion Improved in Non-Diabetic Individuals by Lactobacillus reuteri Supplementation
In this prospective, double-blind, randomized trial, the probiotic strain Lactobacillus reuteri SD5865 at a dosage of 1010 colony-forming units or placebo was provided to non-diabetic individuals twice daily for a period of four weeks to investigate the effect on various parameters associated with blood sugar handling, including secretion of insulin, C-peptide, and glucagon-like peptides-1 and -2.
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Dietary Supplement Use Among the Elderly
A study finds increasing prevalence of polypharmacy and dietary supplement use among older adults and an escalation in risk of drug-drug interactions.