Clinical
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Fertility of Boys Resulting from Intracytoplasmic Sperm Injection
The data from a recent study suggest that at least some men whose fathers had male-factor infertility and were born as a result of ICSI also may suffer from male-factor infertility.
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Ovarian Cancer Screening: Mortality Results
This paper is a 15-year median follow-up of extended mortality of the ovarian cancer screening portion of the Prostate, Lung, Colon, Ovary trial.
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Zika, Revisited
A new study from Brazil shows a very high rate of fetal central nervous system abnormalities with both first-trimester and second-trimester exposure to the Zika virus, compared with data from the United States and other areas in the world where the rate of fetal abnormalities has been lower.
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FDA Action
The FDA has approved a second cyclase-C agonist for the treatment of chronic idiopathic constipation.
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Promising Treatment for Multiple Sclerosis Closer to Approval
Ocrelizumab may be closer to approval for the treatment of progressive multiple sclerosis based on the recently published results of two studies.
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Comparing First-line Treatments for C. difficile Infections
Vancomycin and metronidazole are both used as first-line treatment for C. difficile infections, but vancomycin may be superior in reducing 30-day mortality.
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Approved Drug Demonstrates Efficacy in Battling Potent Bacterial Infection
Bezlotoxumab was associated with a substantially lower rate of recurrent C. difficile infection compared to placebo with a good safety profile.
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Class Action Suit Accuses Pharmaceuticals of Fixing Prices
A class action lawsuit accuses insulin manufacturers of fixing prices and conspiring to increase the cost of their essential medication.
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New Report Raises Red Flags About Antiviral Agents and the Possibility of Liver Failure
The Institute for Safe Medication Practices reported on 524 cases of liver failure in the past 12 months associated with direct-acting antiviral agents for treating hepatitis C.
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A Melodious Path to Addressing Dementia Issues
Clinicians might consider informing involved family members or caretakers of the potential positive effects of music therapy.