Clinical
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The Right Dose at the Right Time: Improving Hypertension Outcomes
An online study of evening vs. morning administration of patients’ usual antihypertensive medications, with a median five-year follow-up, revealed there is no difference in major cardiovascular outcomes between the two periods.
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Are Renal Artery Denervation Efficacy Claims Too Good to Be True?
Three-year follow-up data from the SYMPLICITY HTN-3 trial of renal denervation provide support for long-term safety of this technique and suggest blood pressure benefit.
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MicroRNA Could Help Oncologists Craft Better Treatment Plans for Breast Cancer Patients
Researchers have been searching for biomarkers that are good predictors of cancer recurrence and mortality.
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A Slow But Regular Rhythm Pattern
The tracing was obtained from an older woman with a slow pulse. How should one interpret the ECG?
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The Dental Procedure-Infective Endocarditis Link Controversy Continues
Infective endocarditis was more common with dental surgery or tooth extractions in the preceding four weeks in high-risk patients. Researchers abrogated this risk with antibiotic prophylaxis before the procedure.
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Long-Term Outcomes in Intracerebral, Intraventricular Hemorrhage
It is important to avoid giving a poor prognosis early in the clinical course, and to continue supportive care until the long-term outcome truly is understood.
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Benefits, Risks of Dual Antiplatelet Therapy After Acute Ischemic Stroke or TIA
It will be important to determine the actual frequency of the CYP2C19 loss-of-function gene. Clinicians should consider point-of-care testing for patients before selecting and initiating dual antiplatelet therapy.
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The Great Imitator Imitates Again
This case report serves as a reminder that even though pancolitis from secondary syphilis is rare, syphilitic proctitis is a not-uncommon manifestation of syphilis — and that syphilis can present as almost anything — even long COVID.
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Doxycycline Plus a Beta-Lactam to Treat Inpatients with Community-Acquired Pneumonia
In this retrospective study of an elderly male population hospitalized with community-acquired pneumonia, the combination of doxycycline with a beta-lactam was at least as effective as a respiratory fluoroquinolone or a combination of a beta-lactam with azithromycin.
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Study: STI Rates Increased After Family Planning Clinics Closed in Iowa
The results of a recent study revealed that gonorrhea case rates nearly doubled in Iowa after some publicly funded family planning health centers were closed due to state officials’ efforts to ban abortions. Rates of other STIs also increased significantly.