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Ablation vs. Drug Therapy for Atrial Fibrillation, Revisited

A three-year follow-up of EARLY-AF, a study of relatively young and healthy patients with recent atrial fibrillation, showed cryoablation remains superior to drug therapy for preventing the development of persistent atrial fibrillation.

Outcomes for Patients Undergoing Transcatheter Edge-to-Edge Repair for Functional Mitral Regurgitation

Researchers analyzed transcutaneous mitral valve repair in patients with moderate-to-severe or worse mitral valve regurgitation caused by cardiomyopathy and heart failure despite maximally tolerated guideline-directed medical therapy. Compared to medical therapy alone, undergoing repair resulted in fewer heart failure and other cardiovascular disease hospitalizations and significantly more time free of hospitalization and death.

Does the Completeness of Coronary Revascularization Affect the Outcome of Transcatheter Aortic Valve Replacement?

In this study of data from the REVASC TAVI registry, completeness of myocardial revascularization did not significantly affect the risk of all-cause mortality or the combined endpoint of death, stroke, myocardial infarction, or heart failure hospitalization at two years.

Is AV Block Complete?

Does the ECG in the figure represent complete AV block? If not, why not?

Fecal Microbiota, live-jslm (Rebyota)

Rebyota can be prescribed to prevent recurring Clostridioides difficile infection for patients age 18 years and older who are following antibiotic treatment for recurring episodes.

Is Screening for Atrial Fibrillation Cost Effective?

Self-screening for atrial fibrillation in elderly individuals could lead to lower stroke rates, prevent bleeding-related hospitalizations, and save money.

COVID-19: Beware Remdesivir Resistance

Researchers reported two immunosuppressed renal transplant recipients with persistent SARS-CoV-2 infection in association with the new emergence of mutations in RNA-dependent RNA polymerase after remdesivir treatment.

Triglyceride-Lowering Therapy and Cardiovascular Events

Researchers studied pemafibrate vs. placebo in patients with type 2 diabetes, mild-to-moderate triglyceride elevations, and low levels of HDL and well-controlled LDL cholesterol. Despite a 31% reduction in triglyceride levels, there was no improvement in the risk of cardiovascular outcomes over a median follow-up of 3.4 years.

Is Red Meat Really Unhealthy?

A thorough review of the evidence raises questions about the health risks of eating unprocessed red meat.

Body Weight Decline in Cognitively Intact Older Adults May Predict Future Cognitive Impairment

Among cognitively intact individuals, those who developed mild cognitive impairment (MCI) recorded faster body mass index (BMI) decline and significantly lower BMI seven years before MCI diagnosis.