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Direct Oral Anticoagulants vs. Warfarin When Treating Renal Dysfunction

A patient-level meta-analysis of five pivotal trials of direct oral anticoagulants (DOACs) vs. warfarin for patients with atrial fibrillation and creatinine clearance levels ranging from normal to 25 mL/min revealed standard-dose DOACs exhibit superior safety and efficacy compared to adjusted-dose warfarin and lower-dose DOACs.

The Best Use of Statins in Patients with Coronary Artery Disease

A randomized, multicenter study of high-intensity statin therapy to a treat-to-target approach in coronary artery disease patients showed no difference in three-year outcomes. These results suggest treating to a target may be more suitable to individual patients compared to blanket high-intensity statin use.

A Promising Frontier in Alzheimer’s Treatment

In a multicenter, head-to-head trial, donanemab demonstrated superiority over aducanumab for early symptomatic Alzheimer’s disease patients.

Momentum Continues for Transcatheter Edge-to-Edge Repair

A flurry of recently released study data provided more evidence supporting the efficacy of the minimally invasive heart procedure.

A Hidden Rhythm

The only clinical information available for this tracing is that the ECG was obtained from an older woman. Without any other background, where should we go from here?

Healthy Lifestyles Can Help Reduce Cognitive Decline

In a population-based, prospective cohort study of 29,000 Chinese adults, researchers found healthy lifestyle was associated with slower memory decline, even in the presence of the apolipoprotein E4 allele.

Respiratory Syncytial Virus Vaccine, Adjuvanted (Arexvy)

Arexvy can be administered to prevent lower respiratory tract disease caused by respiratory syncytial virus in patients age 60 years and older.

Patients Managing Severe Hypertension Should Avoid Drinking Too Much Coffee

Among patients with severe hypertension, drinking two or more cups of coffee a day was associated with twice the risk of death from cardiovascular disease, while green tea did not increase risk.

Focused Ultrasound Ablation of the Subthalamic Nucleus for Parkinson’s Disease Tremor

Researchers demonstrated the long-term efficacy and safety of unilateral MRI-guided high-frequency ultrasound subthalamotomy for Parkinson’s disease patients with motor fluctuations and dyskinesia three years after the procedure.

The Effects of Video Feedback on Parenting Children with Behavioral Problems

This randomized trial of an in-home parenting intervention consisting of review of video interactions and feedback promoting positive parenting was associated with fewer behavioral problems in high-risk children (ages 1 to 3 years) compared with usual care.