Browse Clinical Publication Articles by Topic

A Component of Tea to Promote Sleep: A Review of L-theanine as Treatment for Insomnia

This review of eight studies encompassing 417 patients assesses the effectiveness of L-theanine on sleep disorders. Results were inconsistent, but avenues of future study were identified.

What Kind of Bundle Branch Block?

Assuming QRS widening in a supraventricular rhythm is not the result of hyperkalemia or other toxicity, and assuming the patient has not been diagnosed with Wolff-Parkinson-White syndrome, classification of 12-lead ECG conduction disturbances can be simplified into one of three basic categories. The tracing in the figure illustrates this concept.

Donislecel-jujn Allogenic Pancreatic Islet Cellular Suspension (Lantidra)

Lantidra can be prescribed to adults with type 1 diabetes who cannot approach target HbA1c levels because of current repeated episodes of severe hyperglycemia despite intensive diabetes management and education.

Report from the 2023 American Diabetes Association Scientific Sessions

At the 2023 American Diabetes Association Scientific Sessions, experts presented key updates, advances, and best practices for patient care. A selection of presentations relevant to the internal medicine and primary care community is presented here.

Reconsidering Aspirin Therapy for Elderly Patients

A post-hoc analysis of the ASPREE trial revealed that in presumably healthy elderly subjects, taking low-dose aspirin daily over three years was associated with a significant drop in hemoglobin and ferritin levels vs. placebo, even when patients with major bleeding events were excluded.

Can Physical Activity Thwart the Negative Cardiometabolic Effects of Obesity?

Compared to normal-weight workers, overweight or obese employees in Spain exhibited a higher prevalence of risk factors for cardiovascular disease, which can be partially mitigated by regular exercise.

Alcohol: Double-Edged Sword, or Hatchet?

Researchers reported consuming two to 14 alcoholic drinks per week was associated with fewer major adverse cardiovascular events, which the authors noted could be explained in part by less stress-related neural activity demonstrated on PET and CT scans.

The Value of the GRACE Risk Score for Triaging Non-ST-Elevation Acute Coronary Syndrome Patients

A prospective, pragmatic, cluster, randomized clinical study of using the Global Registry of Acute Coronary Events (GRACE) risk score and standard care for the management of non-ST-elevation acute coronary syndromes failed to demonstrate more use of guideline-recommended care or better outcomes.

Angiographic Fractional Flow Reserve Is Useful, But Not Ready for Prime Time

Using a blinded, independent core laboratory, researchers compared five commercially available angiographic fractional flow reserve (FFR) methods to the pressure wire-based FFR technique. The authors found the diagnostic accuracy of these software techniques surpassed that of two-dimensional quantitative coronary angiography, but fell short of what has been reported in validation trials run by individual vendors.

Colchicine Tablets (Lodoco)

The FDA has approved the first anti-inflammatory drug to lower the risk of cardiovascular events occurring in adults with established atherosclerotic disease or with multiple risk factors.