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Exploring the Relationship Between Alcohol and Cardiovascular Events

Researchers reported consuming two to 14 alcoholic drinks per week was associated with fewer major adverse cardiovascular events, which the authors noted could be explained in part by less stress-related neural activity demonstrated on PET and CT scans.

Can Cognitive Behavioral Therapy Help with Insomnia?

In this randomized clinical trial, telephone-administered cognitive behavioral therapy for insomnia significantly outperformed education alone in alleviating insomnia and reducing daytime fatigue in older adults with osteoarthritis pain.

Is the Irregularity a Problem?

Interpreting ECGs without the benefit of any history always is challenging. Such is the case with the figure in this article, which manifests significant irregularity.

COVID-19 Vaccine, 2023-2024 Formula (Comirnaty, Spikevax)

The newest vaccines target XBB.1.5, which is no longer the dominant circulating variant, but they offer protection against XBB.1.16 and more distant variants (e.g., EG.5.1, FL.1.1.1, and BA.2.86).

Steroids and Pneumonia — So Meta?

In a multicenter, randomized, placebo-controlled trial, hydrocortisone lowered mortality rates among patients with severe community-acquired pneumonia.

More Reports of Severe Group A Streptococcal Infection

Around the world, rates of severe illness caused by group A Streptococcus are rising. Possible explanations for the increase include immunity-altering, post-pandemic changes in exposure to respiratory pathogens and the emergence of new pathogenic M strains of Streptococcus.

Glyceryl Trinitrate Topical Gel (Eroxon)

Eroxon can be recommended to treat adult men (age 18 years and older) with erectile dysfunction.

Timing of Anticoagulation Administration Following Atrial Fibrillation-Associated Stroke

A prospective, blinded, randomized study of early vs. later administration of oral anticoagulation after ischemic stroke in patients with atrial fibrillation calibrated by cerebral imaging showed no significant difference in 30-day outcomes.

Researchers Report on the Efficacy of the Subcutaneous Implantable Cardioverter-Defibrillator

An FDA-mandated post-approval study of the subcutaneous cardioverter-defibrillator system in a real-world population revealed excellent safety and efficacy over five years.

Oral Penicillin Challenge vs. Skin Testing: Diagnosing Low-Risk Patients with Reported Penicillin Allergy

In a comparison of direct oral penicillin challenge in low-risk patients to skin testing followed by oral challenge, researchers reported no significant differences. Direct oral penicillin challenge appears to be a safe and effective way to delabel a penicillin allergy.