Cardiology
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Do We Really Know the Optimal Oxygen Target in Patients with ARDS?
In the LOCO2 study, a conservative oxygen strategy with SpO2 goals of 88% to 92% was not shown to improve mortality over a liberal oxygen strategy as hypothesized, but rather was found to have a worrisome signal of increased mortality and increased mesenteric ischemia.
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Management of Pulmonary-Renal Syndrome
The role of the intensivist in the management of pulmonary-renal syndrome includes appropriate respiratory support and recognition and management of concurrent infection, hypovolemia, acute anemia, and coagulopathy.
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Veterans with PTSD, TBI at Much Higher Risk for Heart Attack
Such patients also more likely to experience first attack at a younger age than the general population.
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Remdesivir Injection (Veklury)
Remdesivir’s benefit appears to be modest, but may be better for those receiving low-flow oxygen.
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Can Chopsticks Carry SARS-CoV-2?
This small study suggests salivary contamination of utensils with SARS-CoV-2 virus can occur. Sharing food and utensils, or using communal food bowls, probably is not a good idea if one is trying to avoid COVID-19.
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Possible Aerosol Spread of SARS-CoV-2 in an Apartment Building
Although not definitive, evidence is consistent with aerosol spread of SARS-CoV-2 in an apartment building as a result of transport through the drainage system to apartments directly above.
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A Novel Rifabutin-Containing Combination Regimen Eradicates H. pylori Infection
Researchers found a significantly higher eradication rate for H. pylori with a 14-day regimen of rifabutin, amoxicillin, and omeprazole compared to 14 days of amoxicillin and omeprazole.
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Race Correction in Clinical Calculations: Is It Time to Reconsider?
Many clinical calculators use race as a predictive variable to assess risk for outcomes. Although most tools assume a genetic disposition for these outcomes, other factors, such as health disparities and other potential confounders, are more likely to be the underlying reasons for any race-related differences in outcomes.
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More Is Not Better with Vitamin D Supplementation
A recent study revealed vitamin D levels higher than normal from high-dose supplementation are harmful to bone health.
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Prophylactic PCI for Vulnerable Plaques
In this proof-of-concept trial, treatment of non-flow limiting vulnerable plaque by PCI with bioabsorbable stents resulted in no significant difference in lesion-related events compared with optimal medical therapy, but there was a trend toward less angina driven revascularization in the stented group.