Cardiology
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Relugolix Tablets (Orgovyx)
Relugolix should be prescribed to adults with advanced prostate cancer.
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Prophylactic PCI for Vulnerable Plaques
In this proof-of-concept trial, treatment of non-flow limiting vulnerable plaque by PCI with bioabsorbable stents resulted in no significant difference in lesion-related events compared with optimal medical therapy.
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Does MRSA Nares Colonization Predict Non-Respiratory MRSA Infections?
Nares screening for methicillin-resistant Staphylococcus aureus (MRSA) carried a high negative predictive value to rule out MRSA infections at various sites.
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Air Pollution and Cognitive Decline
In this large prospective cohort study of subjects in Manhattan, researchers demonstrated an association between exposure to air pollution and decline in cognitive function over time in one cohort, but not the other.
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Improve Diet to Put Out the GERD Fire
The authors estimated nearly 40% of gastroesophageal reflux disease symptoms that occur at least weekly can be prevented through a modification of lifestyle factors.
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American Heart Association Acknowledges Psychological, Heart Health Connections
The authors of a scientific statement call for psychological health screening and treatment to be a part of caring for patients at risk for cardiovascular disease.
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Time-Restricted Eating, Weight Loss, and Metabolism
A randomized clinical trial comparing time-restricted eating with a 16-hour fasting interval to a structured three-meal-per-day control group resulted in equivalent weight loss in both groups and no reduction in metabolic markers in either group.
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From Childhood to Adolescence: Metabolic Disturbance Risk Factors
An innovative statistical model examining the development of metabolic disturbances in a large sample of youths finds that having media in a bedroom (associated with higher risk) and belonging to a sports club (associated with lower risk) are among the modifiable risk factors in this population.
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COVID-19 Patients Can Be Managed Safely with Noninvasive Respiratory Strategies
In this retrospective chart review of adult patients hospitalized with COVID-19 over a one-month period, the implementation of a noninvasive respiratory protocol that encouraged high-flow nasal cannula, noninvasive mechanical ventilation, and self-proning did not result in any significant increase in mortality.
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In the Setting of Non-COVID ARDS, Improvement in Oxygenation with Proning Predicts Survival
In this retrospective cohort study, improvement in the PaO2/FiO2 (P/F) ratio by 54% was the optimal cutoff to predict those more likely to be alive at 28 days.