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The Defibrillator in Acute Myocardial Infarction Trial examined the question whether prophylactic implantable cardioverter defibrillator (ICD) therapy begun soon after myocardial infarction would reduce long-term mortality.
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The addition of antiplatelet therapy to reduced intensity anticoagulation in atrial fibrillation patients reduces death and embolic events without increasing bleeding.
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The substantial differences in opinion concerning the need for revascularization prior to elective vascular surgery are present among cardiologists.
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Pravastatin is the statin with the least interactions with cytochrome P450-(CYP) 3A4 inhibitors.
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Atenolol is unsuitable as a first-line drug in hypertension.
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Pharmacotherapy of hypertension has been much in the news in the last 2 months. Standard therapies such as atenolol have been challenged, while calcium channel antagonists may be making a comeback.
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The addition of nifedipine to conventional treatment in patients with chronic stable angina did not affect overall event-free survival, but was safe and reduced the need for coronary interventions.
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