Cardiology
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What Is the ‘Bix Rule?’
The ECG in the figure was obtained from a middle-aged man with a history of exertional chest pain and dyspnea. How would one interpret this tracing? Does the red arrow in lead II show a sinus P wave?
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Atogepant Tablets (Qulipta)
Atogepant can be prescribed to prevent episodic migraine in adults.
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Progression of Coronary Calcium on Statin Treatment
In those treated with statins vs. those who were not, statins decreased plaque volume in plaques with little or no calcium (plaque regression) and increased calcium density without changes in plaque volume in calcified plaques (plaque stabilization).
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Adjuvanted Zoster Vaccine: Persistent Protection
The adjuvanted recombinant zoster vaccine efficacy is high and persistent, with apparent plateauing at > 84% four to six years after vaccination.
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First-Line Therapy for Hypertension
When comparing angiotensin-converting enzyme inhibitors and angiotensin receptor blockers (ARBs) to treat hypertension, researchers observed no difference in major cardiovascular events — but a better safety profile for ARBs.
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Carbohydrates and Insulin Resistance: Pondering Food Quality vs. Quantity
Researchers posit that solving the obesity epidemic is not as simple as eating less and moving more.
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Vitamin D and COVID-19
Low levels of vitamin D are associated with in-hospital mortality in patients with COVID-19, but causality is not yet known.
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Rapid Eye Movement Sleep Duration Is Predictive of Life Expectancy
Total sleep duration declines with older age, as does the fraction of sleep spent in rapid eye movement (REM) sleep. The decline in REM is associated with increasing mortality, but it is unclear if this is a cause or a marker of declining health and declining brain function.
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Cannabis Use and Associated Health Conditions in Primary Care: An EHR Review
This cross-sectional review of 185,565 patients’ medical records revealed documentation of medicinal cannabis use in 2% of the records. Within this subgroup, 44.5% had documentation of one or more health conditions potentially benefitting from treatment with cannabis, 54.4% had documentation of one or more health conditions potentially worsening with cannabis use, and 36.6% had both types of health conditions.
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Is There a Role for Intermediate-Dose Anticoagulation for Critically Ill COVID-19 Patients?
In a multicenter, randomized clinical trial of critically ill COVID-19 patients, intermediate-dose compared to standard-dose prophylactic anticoagulation did not result in significant differences in the rates of venous or arterial thrombosis, treatment with extracorporeal membrane oxygenation, or mortality within 30 days.