Cardiology
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In Addition to the Rhythm
The ECG in the figure was obtained from a middle-aged woman who presented with a febrile illness and shortness of breath. She reported no chest pain. In addition to the rhythm, what else is going on?
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Dihydroergotamine Nasal Spray (Trudhesa)
DHE nasal spray can be prescribed to treat migraine in adults with or without aura.
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Iron Therapy for Acute Heart Failure
Giving intravenous ferric carboxymaltose to stabilized post-acute heart failure patients with iron deficiency improved quality of life vs. placebo-treated patients within four weeks, which persisted during subsequent therapy for up to 24 weeks.
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Proton-Pump Inhibitors and Community-Associated Clostridioides difficile Infection
A nationwide cohort study of adults in Denmark found that proton-pump inhibitor (PPI) use was associated with a moderately increased risk of community-associated Clostridioides difficile infection, and the risk remained elevated up to one year after PPI treatment had ended.
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Clostridioides difficile Infection: Guideline Update
Fidaxomicin is preferred over vancomycin for initial and recurrent cases. Bezlotoxumab is recommended in many cases of recurrent infection and initial infection in patients at high risk of recurrence.
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Can Antibiotics Lead to Colon Cancer?
Swedish researchers saw an association between frequent antibiotic use and proximal colorectal cancer.
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Adverse Effects of Electronic Cigarettes on the Disease-Naïve Oral Microbiome
A robust metagenomic comparison study of the effects of electronic cigarettes on oral microbiomes suggested the unique aerosol component of electronic cigarettes poses increased risk to development of oral cavity disease.
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Aftermath of COVID-19 in Adults
This review of investigations centered on long-term effects following acute COVID-19 illness in adults illustrates an evolving understanding of the aftermath of this viral infection.
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Is There a Difference Between COVID-19 and Non-COVID-19 ARDS?
Comparison of a small COVID-19 acute respiratory distress syndrome (ARDS) cohort with a historical pre-COVID-19 ARDS cohort found some differences in physiologic parameters and biomarkers, but not enough evidence to warrant deviation from known management guidelines.
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Beyond Benzodiazepines: Adjuncts for the Management of Alcohol Withdrawal in the ICU
Although benzodiazepines are the mainstay of prevention and treatment of alcohol withdrawal syndrome, adjunct medications are used increasingly, with the goal of reducing cumulative benzodiazepine exposure and decreasing both hospital and intensive care unit admission and length of stay.