Cardiology
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Clinical Brief
Briefs -
Dulaglutide Injection (Trulicity™)
The FDA has approved a third long-acting, once-weekly, glucagon-like peptide (GLP-1) receptor agonist for the treatment of type 2 diabetes mellitus, joining exenetide ER and albiglutide. Dulaglutide is made up of two identical human-based GLP-1 analogs linked to a modified human IgG4 Fc fragment. This makes the molecule resistant to degradation by DPP-4, slows absorption, reduces renal clearance, and extends the elimination half-life to approximately 5 days. Dulaglutide is marketed by Eli Lilly as Trulicity.
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Angiotensin Receptor Blockers for Hypertension
Angiotensin receptor blockers (ARBs) are often used as first-line therapy for the treatment of systemic hypertension because of their perceived efficacy and relatively low incidence of adverse effects.
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Colchicine for Recurrent Pericarditis
Although colchicine has been shown to be effective for the treatment of acute pericarditis and first recurrences, little information exists about its use in patients with multiple recurrences.
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Statin Use and Cognitive Effects: Not a Brain Drain
Despite earlier concerns by the FDA about adverse effects of statins on cognitive functioning, a meta-analysis of data from more than 28,000 patients enrolled in 18 randomized, placebo-controlled trials of statin therapy failed to show a causal relationship between treatment and adverse neurocognitive effects for patients with and without cognitive impairment.
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Manipulating Degenerative Joint Disease: RCT Shows Short-term Effects
Men with low back pain who received one high-velocity, low-amplitude spinal manipulation had less pain and improvements in disc space and hip and spinal flexion.
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Treatment of Small Intestinal Bacterial Overgrowth with Botanical Therapies Equivalent to Rifaximin
Small intestinal bacterial overgrowth is a condition associated with symptoms of irritable bowel syndrome and extraintestinal manifestations. This study investigates the effectiveness of the antibiotic rifaximin compared to botanical combination therapies for the treatment of the condition as diagnosed by lactulose breath testing.
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The Role of Ginger in Type 2 Diabetes Mellitus
Ginger supplementation exhibits a promising effect on glycemic control, triglyceride levels, and systemic inflammation in type 2 diabetics.
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Emergent Vascular Access: Is Intraosseous Better Than Central Venous Catheter Placement?
In this single-center, prospective, observational study, intraosseous access outperformed central venous catheter placement in terms of first-pass success rates, mean placement times, and complication rates.
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Is Peripheral Intravenous Administration of Vasopressors Really Safe?
The administration of vasoactive medications by peripheral intravenous access is safe and feasible in critically ill, hypotensive patients.