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Elevated troponin i is a nonspecific finding, but suggests a poor prognosis regardless of its cause.
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Ceftobiprole, a novel broad-spectrum cephalosporin with activity against MRSA, was non-inferior to vancomycin plus ceftazidime in a study of complicated skin and skin-structure infections. This is the first β-lactam with reliable activity against methicillin resistant Staphylococcus aureus (MRSA) to be evaluated in advanced-stage clinical trials.
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Randomized studies of neuroprotective agents for ischemic stroke have resulted in a series of failures, as multiple agents, promising in animal models, have failed when applied to human subjects. By contrast, intracerebral hemorrhage (ICH) has been somewhat a "neglected stepsister" when compared to ischemic stroke; it has been studied minimally, despite its high morbidity and mortality.
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Patients with diabetes mellitus make up a substantial proportion of those undergoing percutaneous coronary intervention (PCI), and they are at higher risk for post-procedural complications.
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The atrial fibrillation and congestive heart Failure (AF-CHF) trial was designed to test the hypothesis that a treatment strategy that involved rhythm control would be superior to rate control in patients with heart failure and left ventricular systolic dysfunction.
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It has long been believed, with considerable substantiation, that women have poorer results of percutaneous interventions (PCI) than men, with higher morbidity and mortality rates.
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Following successful reperfusion for acute myocardial infarction (MI) with primary percutaneous coronary intervention (PCI), the persistence of impaired perfusion portends a poor prognosis.
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The endothelin receptor antagonist bosentan has been shown to improve exercise tolerance, hemodynamics, and clinical deterioration in trials of patients with advanced symptoms due to pulmonary hypertension (WHO functional class III and IV).
